CAMK4 (calcium/calmodulin dependent protein kinase IV)

2003-11-01  

Identity

HGNC
CAMK4
LOCATION
5q22.1
LOCUSID
814
ALIAS
CaMK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 814
MIM: 114080
HGNC: 1464
Ensembl: ENSG00000152495

Variants:

dbSNP: 814
ClinVar: 814
TCGA: ENSG00000152495
COSMIC: CAMK4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152495ENST00000282356Q16566
ENSG00000152495ENST00000504544D6RCD6
ENSG00000152495ENST00000508074D6RE65
ENSG00000152495ENST00000512453Q16566
ENSG00000152495ENST00000514007D6REY7
ENSG00000152495ENST00000515231D6RCD6

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Long-term potentiationKEGGko04720
Calcium signaling pathwayKEGGhsa04020
Long-term potentiationKEGGhsa04720
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Cholinergic synapseKEGGhsa04725
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Activation of NMDA receptor upon glutamate binding and postsynaptic eventsREACTOMER-HSA-442755
Post NMDA receptor activation eventsREACTOMER-HSA-438064
CREB phosphorylation through the activation of CaMKKREACTOMER-HSA-442717
Activation of CaMK IVREACTOMER-HSA-442745
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
DAG and IP3 signalingREACTOMER-HSA-1489509
CaM pathwayREACTOMER-HSA-111997
Calmodulin induced eventsREACTOMER-HSA-111933
CaMK IV-mediated phosphorylation of CREBREACTOMER-HSA-111932
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
EGFR interacts with phospholipase C-gammaREACTOMER-HSA-212718
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PLC-gamma1 signallingREACTOMER-HSA-167021
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by GPCRREACTOMER-HSA-372790
Opioid SignallingREACTOMER-HSA-111885
G-protein mediated eventsREACTOMER-HSA-112040
PLC beta mediated eventsREACTOMER-HSA-112043
Ca-dependent eventsREACTOMER-HSA-111996
Aldosterone synthesis and secretionKEGGhsa04925
Aldosterone synthesis and secretionKEGGko04925
Longevity regulating pathwayKEGGhsa04211
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382870122024CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses.1
382870122024CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses.1
360020212022CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation.3
360020212022CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation.3
337842562021Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis.18
337842562021Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis.18
319767612020Associations of rs2300782 CAMK4, rs2292239 ERBB3 and rs10491034 ARHGAP22 with Diabetic Retinopathy Among Chinese Hui Population.0
319788012020Comparative transcriptome analysis reveals a potential role for CaMK4 in γδT17 cells from systemic lupus erythematosus patients with lupus nephritis.0
324607942020CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis.7
325728972020MiR-507 inhibits the growth and invasion of trophoblasts by targeting CAMK4.4
327381702020CaMK4 promotes abortion-related Th17 cell imbalance by activating AKT/mTOR signaling pathway.2
319767612020Associations of rs2300782 CAMK4, rs2292239 ERBB3 and rs10491034 ARHGAP22 with Diabetic Retinopathy Among Chinese Hui Population.0
319788012020Comparative transcriptome analysis reveals a potential role for CaMK4 in γδT17 cells from systemic lupus erythematosus patients with lupus nephritis.0
324607942020CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis.7
325728972020MiR-507 inhibits the growth and invasion of trophoblasts by targeting CAMK4.4

Citation

Dessen P

CAMK4 (calcium/calmodulin dependent protein kinase IV)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/906/cancer-prone-explorer/gene-fusions-explorer/js/lib/popper.js