CASP14 (caspase 14)

2003-08-01  

Identity

HGNC
CASP14
LOCATION
19p13.12
LOCUSID
23581
ALIAS
ARCI12
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23581
MIM: 605848
HGNC: 1502
Ensembl: ENSG00000105141

Variants:

dbSNP: 23581
ClinVar: 23581
TCGA: ENSG00000105141
COSMIC: CASP14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105141ENST00000427043P31944
ENSG00000105141ENST00000427043B2CIS9

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567
Formation of the cornified envelopeREACTOMER-HSA-6809371

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
340703822021Caspase-14-From Biomolecular Basics to Clinical Approach. A Review of Available Data.11
340703822021Caspase-14-From Biomolecular Basics to Clinical Approach. A Review of Available Data.11
285707472017Caspase14 expression is associated with triple negative phenotypes and cancer stem cell marker expression in breast cancer patients.13
285707472017Caspase14 expression is associated with triple negative phenotypes and cancer stem cell marker expression in breast cancer patients.13
256513792015S100A7 acts as a dual regulator in promoting proliferation and suppressing squamous differentiation through GATA-3/caspase-14 pathway in A431 cells.8
256513792015S100A7 acts as a dual regulator in promoting proliferation and suppressing squamous differentiation through GATA-3/caspase-14 pathway in A431 cells.8
248724192014Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation.8
251210972014Caspase-14 expression impairs retinal pigment epithelium barrier function: potential role in diabetic macular edema.14
253152962014Pyrrolidone carboxylic acid levels or caspase-14 expression in the corneocytes of lesional skin correlates with clinical severity, skin barrier function and lesional inflammation in atopic dermatitis.17
248724192014Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation.8
251210972014Caspase-14 expression impairs retinal pigment epithelium barrier function: potential role in diabetic macular edema.14
253152962014Pyrrolidone carboxylic acid levels or caspase-14 expression in the corneocytes of lesional skin correlates with clinical severity, skin barrier function and lesional inflammation in atopic dermatitis.17
233628692013Ceramides stimulate caspase-14 expression in human keratinocytes.11
233771372013Expression of caspase-14 and keratin-19 in the human epidermis and appendages during fetal skin development.6
234084452013Genetic variants of AICDA/CASP14 associated with childhood brain tumor.4

Citation

Dessen P

CASP14 (caspase 14)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/918/gene-fusions/case-report-explorer/haematological-explorer/