CAV2 (caveolin 2)

2003-11-01  

Identity

HGNC
CAV2
LOCATION
7q31.2
LOCUSID
858
ALIAS
CAV
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 858
MIM: 601048
HGNC: 1528
Ensembl: ENSG00000105971

Variants:

dbSNP: 858
ClinVar: 858
TCGA: ENSG00000105971
COSMIC: CAV2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105971ENST00000222693P51636
ENSG00000105971ENST00000222693Q53X57
ENSG00000105971ENST00000343213P51636
ENSG00000105971ENST00000393480E9PCT3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
Focal adhesionKEGGhsa04510
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Bacterial invasion of epithelial cellsKEGGko05100
Bacterial invasion of epithelial cellsKEGGhsa05100
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
364995242022Biochemical and Biophysical Characterization of the Caveolin-2 Interaction with Membranes and Analysis of the Protein Structural Alteration by the Presence of Cholesterol.1
364995242022Biochemical and Biophysical Characterization of the Caveolin-2 Interaction with Membranes and Analysis of the Protein Structural Alteration by the Presence of Cholesterol.1
339750602021A genetic variant conferred high expression of CAV2 promotes pancreatic cancer progression and associates with poor prognosis.10
340784022021Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis.27
339750602021A genetic variant conferred high expression of CAV2 promotes pancreatic cancer progression and associates with poor prognosis.10
340784022021Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis.27
321098452020Caveolin proteins electrochemical oxidation and interaction with cholesterol.4
321624262020Association of the CAV1-CAV2 locus with normal-tension glaucoma in Chinese and Japanese.10
321098452020Caveolin proteins electrochemical oxidation and interaction with cholesterol.4
321624262020Association of the CAV1-CAV2 locus with normal-tension glaucoma in Chinese and Japanese.10
318890282019Genetic prediction models for primary open-angle glaucoma: translational research.0
318890282019Genetic prediction models for primary open-angle glaucoma: translational research.0
288572382018The diversity in the expression profile of caveolin II transcripts, considering its new transcript in breast cancer.5
291118462018Investigation of CAV1/CAV2 rs4236601 and CDKN2B-AS1 rs2157719 in primary open-angle glaucoma patients from Brazil.9
296043342018Alternative translation initiation of Caveolin-2 desensitizes insulin signaling through dephosphorylation of insulin receptor by PTP1B and causes insulin resistance.4

Citation

Dessen P

CAV2 (caveolin 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/933