CBX3 (chromobox 3)

2003-05-01  

Identity

HGNC
CBX3
LOCATION
7p15.2
LOCUSID
11335
ALIAS
HECH,HP1-GAMMA,HP1Hs-gamma
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11335
MIM: 604477
HGNC: 1553
Ensembl: ENSG00000122565

Variants:

dbSNP: 11335
ClinVar: 11335
TCGA: ENSG00000122565
COSMIC: CBX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122565ENST00000337620Q13185
ENSG00000122565ENST00000337620A4D177
ENSG00000122565ENST00000396386Q13185
ENSG00000122565ENST00000396386A4D177
ENSG00000122565ENST00000409747B8ZZ43
ENSG00000122565ENST00000456948C9JMM0
ENSG00000122565ENST00000462165S4R2Y4

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Chain ElongationREACTOMER-HSA-73777
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Positive epigenetic regulation of rRNA expressionREACTOMER-HSA-5250913
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionREACTOMER-HSA-427389

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366208762023CBX3 promotes breast cancer progression and high level of CBX3 predicts poor prognosis in patients.0
374360742023PSMC4 promotes prostate carcinoma progression by regulating the CBX3-EGFR-PI3K-AKT-mTOR pathway.4
376742042023CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity.0
366208762023CBX3 promotes breast cancer progression and high level of CBX3 predicts poor prognosis in patients.0
374360742023PSMC4 promotes prostate carcinoma progression by regulating the CBX3-EGFR-PI3K-AKT-mTOR pathway.4
376742042023CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity.0
350484612022Clinicopathological significance of CBX3 in colorectal cancer: An intensive expression study based on formalin-fixed and paraffin-embedded tissues.3
351728032022Comprehensive pan-cancer analysis on CBX3 as a prognostic and immunological biomarker.6
354597802022CBX3 accelerates the malignant progression of glioblastoma multiforme by stabilizing EGFR expression.10
354711482022CBX3 regulated by miR-139 promotes the development of HCC by regulating cell cycle progression.5
356379522022CBX3 Regulated By YBX1 Promotes Smoking-induced Pancreatic Cancer Progression via Inhibiting SMURF2 Expression.8
364007692022The Heterochromatin protein 1 is a regulator in RNA splicing precision deficient in ulcerative colitis.6
350484612022Clinicopathological significance of CBX3 in colorectal cancer: An intensive expression study based on formalin-fixed and paraffin-embedded tissues.3
351728032022Comprehensive pan-cancer analysis on CBX3 as a prognostic and immunological biomarker.6
354597802022CBX3 accelerates the malignant progression of glioblastoma multiforme by stabilizing EGFR expression.10

Citation

Dessen P

CBX3 (chromobox 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/936