CCL11 (C-C motif chemokine ligand 11)

2003-05-01 Affiliation

Identity

HGNC

CCL11

LOCATION

17q12

LOCUSID

6356

ALIAS

SCYA11

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6356
MIM: 601156
HGNC: 10610
Ensembl: ENSG00000172156

Variants:

dbSNP: 6356
ClinVar: 6356
TCGA: ENSG00000172156
COSMIC: CCL11

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000172156	ENST00000305869	P51671
ENSG00000172156	ENST00000305869	Q6I9T4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Asthma	KEGG	ko05310
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Asthma	KEGG	hsa05310
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-4 and 13 signaling	REACTOME	R-HSA-6785807
IL-17 signaling pathway	KEGG	ko04657
IL-17 signaling pathway	KEGG	hsa04657

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA166123307	insomnia	Disease	VariantAnnotation	associated	PD	29222992
PA445043	Opioid-Related Disorders	Disease	ClinicalAnnotation, VariantAnnotation	associated	PD	29222992
PA450401	methadone	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD	29222992

References

Pubmed ID	Year	Title	Citations
38195933	2024	Autotaxin-lysolipid signaling suppresses a CCL11-eosinophil axis to promote pancreatic cancer progression.	0
38305920	2024	Exploring CCL11 in breast cancer: unraveling its anticancer potential and immune modulatory effects involving the Akt-S6 signaling.	0
38394497	2024	Association between CCL5, CCL11, and CCL17 polymorphisms and atopic dermatitis risk: A systematic review and meta-analysis.	1
38195933	2024	Autotaxin-lysolipid signaling suppresses a CCL11-eosinophil axis to promote pancreatic cancer progression.	0
38305920	2024	Exploring CCL11 in breast cancer: unraveling its anticancer potential and immune modulatory effects involving the Akt-S6 signaling.	0
38394497	2024	Association between CCL5, CCL11, and CCL17 polymorphisms and atopic dermatitis risk: A systematic review and meta-analysis.	1
36576886	2023	Bidirectional Mendelian Randomisation Analysis Provides Evidence for the Causal Involvement of Dysregulation of CXCL9, CCL11 and CASP8 in the Pathogenesis of Ulcerative Colitis.	4
37860000	2023	Eotaxin-1/CCL11 promotes cellular senescence in human-derived fibroblasts through pro-oxidant and pro-inflammatory pathways.	1
36576886	2023	Bidirectional Mendelian Randomisation Analysis Provides Evidence for the Causal Involvement of Dysregulation of CXCL9, CCL11 and CASP8 in the Pathogenesis of Ulcerative Colitis.	4
37860000	2023	Eotaxin-1/CCL11 promotes cellular senescence in human-derived fibroblasts through pro-oxidant and pro-inflammatory pathways.	1
34571176	2022	Increase in plasma CCL11 (Eotaxin-1) in patients with alcohol dependence and changes during detoxification.	4
35254015	2022	Eotaxin-1 Levels in Patients with Myocardial Infarction.	4
35690992	2022	Eotaxin-1 (CCL11) in neuroinflammatory disorders and possible role in COVID-19 neurologic complications.	19
34571176	2022	Increase in plasma CCL11 (Eotaxin-1) in patients with alcohol dependence and changes during detoxification.	4
35254015	2022	Eotaxin-1 Levels in Patients with Myocardial Infarction.	4

Citation

Dessen P

CCL11 (C-C motif chemokine ligand 11)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/939/tumors-explorer/js/lib/favicon/apple-touch-icon.png