Identity
HGNC
LOCATION
17q12
LOCUSID
ALIAS
GDCF-2,HC11,HSMCR30,MCAF,MCP-1,MCP1,SCYA2,SMC-CF
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6347
MIM: 158105
HGNC: 10618
Ensembl: ENSG00000108691
Variants:
dbSNP: 6347
ClinVar: 6347
TCGA: ENSG00000108691
COSMIC: CCL2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000108691 | ENST00000225831 | P13500 |
| ENSG00000108691 | ENST00000580907 | J3KRT7 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | 24495780 | |
| PA451257 | risperidone | Chemical | ClinicalAnnotation | associated | PD | 24495780 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35658112 | 2024 | Hypoxia-induced miR-210-3p expression in lung adenocarcinoma potentiates tumor development by regulating CCL2 mediated monocyte infiltration. | 5 |
| 37850256 | 2024 | CCL2 promotes metastasis and epithelial-mesenchymal transition of non-small cell lung cancer via PI3K/Akt/mTOR and autophagy pathways. | 4 |
| 38169464 | 2024 | Association Between Plasma Levels of Monocyte Chemoattractant Protein-1 (MCP-1) and 28-Day Mortality in Elderly Patients with Sepsis: A Retrospective Single-Center Study. | 0 |
| 38181585 | 2024 | FNDC4 reduces inflammation, proliferation, invasion and migration of rheumatoid synovial cells by inhibiting CCL2/ERK signaling. | 0 |
| 38244764 | 2024 | Association of CC-chemokine ligand-2 gene polymorphisms with leprosy reactions. | 0 |
| 38316963 | 2024 | Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway. | 0 |
| 38332001 | 2024 | Exploring the relations of NLR, hsCRP and MCP-1 with type 2 diabetic kidney disease: a cross-sectional study. | 0 |
| 38348687 | 2024 | BRG1 mediates epigenetic regulation of TNFα-induced CCL2 expression in oral tongue squamous cell carcinoma cells. | 0 |
| 38387908 | 2024 | [Expression of MCP-1 and CCR2 in Newly Diagnosed Diffuse Large B-Cell Lymphoma and Clinical Significance]. | 0 |
| 38428413 | 2024 | Activated mesenchymal stem/stromal cells promote myeloid cell differentiation via CCL2/CCR2 signaling. | 0 |
| 38593506 | 2024 | MCP-1 controls IL-17-promoted monocyte migration and M1 polarization in osteoarthritis. | 0 |
| 38724995 | 2024 | Epithelial cells derived exosomal miR-203a-3p facilitates stromal inflammation of type IIIA chronic prostatitis/chronic pelvic pain syndrome by targeting DUSP5 and increasing MCP-1 generation. | 0 |
| 35658112 | 2024 | Hypoxia-induced miR-210-3p expression in lung adenocarcinoma potentiates tumor development by regulating CCL2 mediated monocyte infiltration. | 5 |
| 37850256 | 2024 | CCL2 promotes metastasis and epithelial-mesenchymal transition of non-small cell lung cancer via PI3K/Akt/mTOR and autophagy pathways. | 4 |
| 38169464 | 2024 | Association Between Plasma Levels of Monocyte Chemoattractant Protein-1 (MCP-1) and 28-Day Mortality in Elderly Patients with Sepsis: A Retrospective Single-Center Study. | 0 |
Citation
Dessen P
CCL2 (C-C motif chemokine ligand 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/942/ccl2
