CCL3 (C-C motif chemokine ligand 3)

2003-08-01  

Identity

HGNC
CCL3
LOCATION
17q12
LOCUSID
6348
ALIAS
G0S19-1,LD78ALPHA,MIP-1-alpha,MIP1A,SCYA3

Other Information

Locus ID:

NCBI: 6348
MIM: 182283
HGNC: 10627
Ensembl: ENSG00000277632

Variants:

dbSNP: 6348
ClinVar: 6348
TCGA: ENSG00000277632
COSMIC: CCL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000277632ENST00000613922P10147
ENSG00000277632ENST00000613922A0N0R1

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Toll-like receptor signaling pathwayKEGGko04620
Cytokine-cytokine receptor interactionKEGGhsa04060
Toll-like receptor signaling pathwayKEGGhsa04620
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-10 signalingREACTOMER-HSA-6783783

References

Pubmed IDYearTitleCitations
384376462024Chronic Stress Exacerbates the Immunosuppressive Microenvironment and Progression of Gliomas by Reducing Secretion of CCL3.0
384852502024Utility of peripheral protein biomarkers for the prediction of incident interstitial features: a multicentre retrospective cohort study.0
387971552024KAT7 serves as an oncogenic gene and regulates CCL3 expression via STAT1 signaling in osteosarcoma.0
384376462024Chronic Stress Exacerbates the Immunosuppressive Microenvironment and Progression of Gliomas by Reducing Secretion of CCL3.0
384852502024Utility of peripheral protein biomarkers for the prediction of incident interstitial features: a multicentre retrospective cohort study.0
387971552024KAT7 serves as an oncogenic gene and regulates CCL3 expression via STAT1 signaling in osteosarcoma.0
366910462023CCL3 secreted by hepatocytes promotes the metastasis of intrahepatic cholangiocarcinoma by VIRMA-mediated N6-methyladenosine (m(6)A) modification.4
370151912023CCL3 as Possible Negative Prognostic Factor in Chronic Lymphocytic Leukemia.0
374780262023Increased circulating levels of MIP-1α and CD14 are associated with the presence of severe stenosis and hypoechoic plaques in patients with carotid atherosclerosis.1
366910462023CCL3 secreted by hepatocytes promotes the metastasis of intrahepatic cholangiocarcinoma by VIRMA-mediated N6-methyladenosine (m(6)A) modification.4
370151912023CCL3 as Possible Negative Prognostic Factor in Chronic Lymphocytic Leukemia.0
374780262023Increased circulating levels of MIP-1α and CD14 are associated with the presence of severe stenosis and hypoechoic plaques in patients with carotid atherosclerosis.1
353570572022Associations between vaginal flora, MIP-1α, IL-17A, and clinical pregnancy rate in AIH.0
356138262022Ccl3 enhances docetaxel chemosensitivity in breast cancer by triggering proinflammatory macrophage polarization.9
353570572022Associations between vaginal flora, MIP-1α, IL-17A, and clinical pregnancy rate in AIH.0

Citation

Dessen P

CCL3 (C-C motif chemokine ligand 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/944