LCP1 (lymphocyte cytosolic protein1)
1998-03-01 Sylvie Galiègue-Zouitina AffiliationU.124 INSERM, I.R.C.L., Place de Verdun, 59045 LILLE Cedex, France
Identity
HGNC
LOCATION
13q14.13
LOCUSID
ALIAS
CP64,HEL-S-37,L-PLASTIN,LC64P,LPL,PLS2
FUSION GENES
DNA/RNA
Description
spans on a 90 kb genomic fragment; 16 exons, large first intron (20kb)
Transcription
3.7 kb mRNA; coding sequence from exon 2 to exon 16: 3500 bp
Proteins
Description
570 amino acids
Expression
restricted to the hematopoietic cells (leukocytes); expression
induced in all tumor cells of all tissues
Localisation
membrane
Homology
belongs to an actin-binding protein family (T-Plastin, Fimbrin, I-Plastin)
Implicated in
Entity name
Disease
non Hodgkin follicular as well as Burkitt lymphomas
Cytogenetics
t(3;13) is observed as a secondary anomaly
Hybrid gene
both 5 L-Plastin- 3 BCL6 and 5 BCL6 - 3 L-Plastin, leading
to two fusion transcripts
Fusion protein
no fusion protein, but promoter exchange between both partner genes
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9666807 | 1998 | Cytogenetics in multiple myeloma: a multicenter study of 24 patients with t(11;14)(q13;q32) or its variant. | Laï JL et al |
| 3211125 | 1988 | Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts. | Lin CS et al |
| 8428952 | 1993 | Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells. | Lin CS et al |
| 8137292 | 1994 | Activation of the leukocyte plastin gene occurs in most human cancer cells. | Park T et al |
| 9017597 | 1997 | Interaction of a Dictyostelium member of the plastin/fimbrin family with actin filaments and actin-myosin complexes. | Prassler J et al |
Other Information
Locus ID:
NCBI: 3936
MIM: 153430
HGNC: 6528
Ensembl: ENSG00000136167
Variants:
dbSNP: 3936
ClinVar: 3936
TCGA: ENSG00000136167
COSMIC: LCP1
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35578065 | 2022 | Transcriptome Profiling Analysis Identifies LCP1 as a Contributor for Chidamide Resistance in Gastric Cancer. | 2 |
| 35995384 | 2022 | Targeted proteomics using parallel reaction monitoring confirms salivary proteins indicative of metastatic triple-negative breast cancer. | 2 |
| 35578065 | 2022 | Transcriptome Profiling Analysis Identifies LCP1 as a Contributor for Chidamide Resistance in Gastric Cancer. | 2 |
| 35995384 | 2022 | Targeted proteomics using parallel reaction monitoring confirms salivary proteins indicative of metastatic triple-negative breast cancer. | 2 |
| 32986657 | 2021 | LCP1 is a prognostic biomarker correlated with immune infiltrates in gastric cancer. | 6 |
| 32986657 | 2021 | LCP1 is a prognostic biomarker correlated with immune infiltrates in gastric cancer. | 6 |
| 32859369 | 2020 | The actin-bundling protein L-plastin-A double-edged sword: Beneficial for the immune response, maleficent in cancer. | 4 |
| 32859369 | 2020 | The actin-bundling protein L-plastin-A double-edged sword: Beneficial for the immune response, maleficent in cancer. | 4 |
| 31501427 | 2019 | Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells. | 17 |
| 31501427 | 2019 | Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells. | 17 |
| 29882856 | 2018 | Inhibition of HIF1α-Dependent Upregulation of Phospho-l-Plastin Resensitizes Multiple Myeloma Cells to Frontline Therapy. | 5 |
| 30333137 | 2018 | LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. | 10 |
| 29882856 | 2018 | Inhibition of HIF1α-Dependent Upregulation of Phospho-l-Plastin Resensitizes Multiple Myeloma Cells to Frontline Therapy. | 5 |
| 30333137 | 2018 | LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. | 10 |
| 27720134 | 2017 | L-plastin regulates the stability of the immune synapse of naive and effector T-cells. | 14 |
Citation
Sylvie Galiègue-Zouitina
LCP1 (lymphocyte cytosolic protein1)
Atlas Genet Cytogenet Oncol Haematol. 1998-03-01
Online version: http://atlasgeneticsoncology.org/gene/95/lcp1
