CCNC (cyclin C)

2003-02-01 Affiliation

Identity

HGNC

CCNC

LOCATION

6q16.2

LOCUSID

892

ALIAS

CycC,SRB11,hSRB11

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 892
MIM: 123838
HGNC: 1581
Ensembl: ENSG00000112237

Variants:

dbSNP: 892
ClinVar: 892
TCGA: ENSG00000112237
COSMIC: CCNC

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000112237	ENST00000326298	G5E954
ENSG00000112237	ENST00000369217	E5RI39
ENSG00000112237	ENST00000369220	J3KP90
ENSG00000112237	ENST00000482541	Q5JV82
ENSG00000112237	ENST00000484049	E5RIH8
ENSG00000112237	ENST00000486428	H0YBQ5
ENSG00000112237	ENST00000518714	E5RFK5
ENSG00000112237	ENST00000520371	E5RFK5
ENSG00000112237	ENST00000520429	P24863
ENSG00000112237	ENST00000520429	Q7Z4L3
ENSG00000112237	ENST00000523799	P24863
ENSG00000112237	ENST00000523961	E5RHL8
ENSG00000112237	ENST00000523985	P24863
ENSG00000112237	ENST00000524049	E5RFX8
ENSG00000112237	ENST00000627680	G5E954

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Signaling by NOTCH1 in Cancer	REACTOME	R-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in Cancer	REACTOME	R-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain Mutants	REACTOME	R-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	REACTOME	R-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	REACTOME	R-HSA-2894862
Signal Transduction	REACTOME	R-HSA-162582
Signaling by TGF-beta Receptor Complex	REACTOME	R-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	REACTOME	R-HSA-2173793
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	REACTOME	R-HSA-2173796
Signaling by NOTCH	REACTOME	R-HSA-157118
Signaling by NOTCH1	REACTOME	R-HSA-1980143
NOTCH1 Intracellular Domain Regulates Transcription	REACTOME	R-HSA-2122947
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	REACTOME	R-HSA-400206
PPARA activates gene expression	REACTOME	R-HSA-1989781
Developmental Biology	REACTOME	R-HSA-1266738
Transcriptional regulation of white adipocyte differentiation	REACTOME	R-HSA-381340

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
34197614	2021	Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2.	9
34329458	2021	Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress.	17
34197614	2021	Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2.	9
34329458	2021	Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress.	17
30516433	2019	Cyclin C directly stimulates Drp1 GTP affinity to mediate stress-induced mitochondrial hyperfission.	22
30516433	2019	Cyclin C directly stimulates Drp1 GTP affinity to mediate stress-induced mitochondrial hyperfission.	22
29440396	2018	Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.	32
29440396	2018	Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.	32
25986860	2015	Cyclin C interacts with steroid receptor coactivator 2 and upregulates cell cycle genes in MCF-7 cells.	2
26042770	2015	mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC).	17
25986860	2015	Cyclin C interacts with steroid receptor coactivator 2 and upregulates cell cycle genes in MCF-7 cells.	2
26042770	2015	mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC).	17
24754906	2014	All-atomic molecular dynamic studies of human CDK8: insight into the A-loop, point mutations and binding with its partner CycC.	12
25344755	2014	Cyclin C is a haploinsufficient tumour suppressor.	69
24754906	2014	All-atomic molecular dynamic studies of human CDK8: insight into the A-loop, point mutations and binding with its partner CycC.	12

Citation

Dessen P

CCNC (cyclin C)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/954