CCND3 (cyclin D3)

2003-02-01  

Identity

HGNC
CCND3
LOCATION
6p21.1
LOCUSID
896
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 896
MIM: 123834
HGNC: 1585
Ensembl: ENSG00000112576

Variants:

dbSNP: 896
ClinVar: 896
TCGA: ENSG00000112576
COSMIC: CCND3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112576ENST00000372987Q5T8J1
ENSG00000112576ENST00000372988P30281
ENSG00000112576ENST00000372991P30281
ENSG00000112576ENST00000414200P30281
ENSG00000112576ENST00000415497P30281
ENSG00000112576ENST00000502771D6RDL3
ENSG00000112576ENST00000505064D6RIX2
ENSG00000112576ENST00000508143A0A1D5RMS0
ENSG00000112576ENST00000510503D6RI00
ENSG00000112576ENST00000511642P30281
ENSG00000112576ENST00000512426H0Y8M4
ENSG00000112576ENST00000514588D6RDF8
ENSG00000112576ENST00000616010P30281

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
p53 signaling pathwayKEGGko04115
Wnt signaling pathwayKEGGko04310
Focal adhesionKEGGko04510
Jak-STAT signaling pathwayKEGGko04630
Cell cycleKEGGhsa04110
p53 signaling pathwayKEGGhsa04115
Wnt signaling pathwayKEGGhsa04310
Focal adhesionKEGGhsa04510
Jak-STAT signaling pathwayKEGGhsa04630
MeaslesKEGGko05162
MeaslesKEGGhsa05162
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Cell cycle - G1/S transitionKEGGhsa_M00692
Cell cycle - G1/S transitionKEGGM00692
Signal TransductionREACTOMER-HSA-162582
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1 PhaseREACTOMER-HSA-69236
Cyclin D associated events in G1REACTOMER-HSA-69231
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
369651652023Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3.1
369651652023Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3.1
361616612022Cyclin D3 restricts SARS-CoV-2 envelope incorporation into virions and interferes with viral spread.5
361616612022Cyclin D3 restricts SARS-CoV-2 envelope incorporation into virions and interferes with viral spread.5
340567352021CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR-34a.9
341033012021Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia.8
344067912021Keratin 19 interacts with GSK3β to regulate its nuclear accumulation and degradation of cyclin D3.2
340567352021CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR-34a.9
341033012021Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia.8
344067912021Keratin 19 interacts with GSK3β to regulate its nuclear accumulation and degradation of cyclin D3.2
305381352019CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1(-) mantle cell lymphoma.42
309112812019Hes3 Enhances the Malignant Phenotype of Lung Cancer through Upregulating Cyclin D1, Cyclin D3 and MMP7 Expression.3
309502412019Prognostic role of cyclin D2/D3 in multiple human malignant neoplasms: A systematic review and meta-analysis.29
305381352019CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1(-) mantle cell lymphoma.42
309112812019Hes3 Enhances the Malignant Phenotype of Lung Cancer through Upregulating Cyclin D1, Cyclin D3 and MMP7 Expression.3

Citation

Dessen P

CCND3 (cyclin D3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/955/img/haematological-explorer/js/lib/zoomerang.js