CD33 (CD33 molecule)

2003-11-01  

Identity

HGNC
CD33
LOCATION
19q13.41
LOCUSID
945
ALIAS
SIGLEC-3,SIGLEC3,p67
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 945
MIM: 159590
HGNC: 1659
Ensembl: ENSG00000105383

Variants:

dbSNP: 945
ClinVar: 945
TCGA: ENSG00000105383
COSMIC: CD33

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105383ENST00000262262P20138
ENSG00000105383ENST00000262262Q546G0
ENSG00000105383ENST00000391796P20138
ENSG00000105383ENST00000421133P20138
ENSG00000105383ENST00000436584B4DF51

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hematopoietic cell lineageKEGGko04640
Hematopoietic cell lineageKEGGhsa04640
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164749431gemtuzumab ozogamicinChemicalClinicalAnnotation, VariantAnnotationassociatedPD
PA166123207overall survivalDiseaseVariantAnnotationassociatedPD
PA444760Leukemia, Myeloid, AcuteDiseaseClinicalAnnotation, VariantAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
359409422023CD33 isoforms in microglia and Alzheimer's disease: Friend and foe.10
368312692023Alzheimer's Disease-Associated Alternative Splicing of CD33 Is Regulated by the HNRNPA Family Proteins.0
370815612023CD33 as a leukocyte-associated marker expressed on human spermatozoa.1
374791762023CD33 polymorphisms and Parkinson's disease Parkinson's disease in northern Chinese Han population: A case-control study.0
375065572023Plasma proteomic profiling identifies CD33 as a marker of HIV control in natural infection and after therapeutic vaccination.1
375191832023Lack of Association between CD33 rs3865444 and Amyotrophic Lateral Sclerosis: A Case-Control Study.0
359409422023CD33 isoforms in microglia and Alzheimer's disease: Friend and foe.10
368312692023Alzheimer's Disease-Associated Alternative Splicing of CD33 Is Regulated by the HNRNPA Family Proteins.0
370815612023CD33 as a leukocyte-associated marker expressed on human spermatozoa.1
374791762023CD33 polymorphisms and Parkinson's disease Parkinson's disease in northern Chinese Han population: A case-control study.0
375065572023Plasma proteomic profiling identifies CD33 as a marker of HIV control in natural infection and after therapeutic vaccination.1
375191832023Lack of Association between CD33 rs3865444 and Amyotrophic Lateral Sclerosis: A Case-Control Study.0
351236182022[The Relationship between the Expressions of CD33 and CD13 and the Prognosis of Patients with Multiple Myeloma].0
354089902022CD33 rs2455069 SNP: Correlation with Alzheimer's Disease and Hypothesis of Functional Role.7
360513602022No Evidence that CD33 rs12459419 Polymorphism Predicts Gemtuzumab Ozogamicin Response in Consolidation Treatment of Acute Myeloid Leukemia Patients: Experience of the PETHEMA Group.0

Citation

Dessen P

CD33 (CD33 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/974/js/lib/css/haematological-explorer/