CD33 (CD33 molecule)

2003-11-01  

Identity

HGNC
LOCATION
19q13.41
LOCUSID
ALIAS
SIGLEC-3,SIGLEC3,p67
FUSION GENES

Other Information

Locus ID:

NCBI: 945
MIM: 159590
HGNC: 1659
Ensembl: ENSG00000105383

Variants:

dbSNP: 945
ClinVar: 945
TCGA: ENSG00000105383
COSMIC: CD33

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105383ENST00000262262P20138
ENSG00000105383ENST00000262262Q546G0
ENSG00000105383ENST00000391796P20138
ENSG00000105383ENST00000421133P20138
ENSG00000105383ENST00000436584B4DF51

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Hematopoietic cell lineageKEGGko04640
Hematopoietic cell lineageKEGGhsa04640
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164749431gemtuzumab ozogamicinChemicalClinicalAnnotation, VariantAnnotationassociatedPD
PA166123207overall survivalDiseaseVariantAnnotationassociatedPD
PA444760Leukemia, Myeloid, AcuteDiseaseClinicalAnnotation, VariantAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
359409422023CD33 isoforms in microglia and Alzheimer's disease: Friend and foe.10
368312692023Alzheimer's Disease-Associated Alternative Splicing of CD33 Is Regulated by the HNRNPA Family Proteins.0
370815612023CD33 as a leukocyte-associated marker expressed on human spermatozoa.1
374791762023CD33 polymorphisms and Parkinson's disease Parkinson's disease in northern Chinese Han population: A case-control study.0
375065572023Plasma proteomic profiling identifies CD33 as a marker of HIV control in natural infection and after therapeutic vaccination.1
375191832023Lack of Association between CD33 rs3865444 and Amyotrophic Lateral Sclerosis: A Case-Control Study.0
359409422023CD33 isoforms in microglia and Alzheimer's disease: Friend and foe.10
368312692023Alzheimer's Disease-Associated Alternative Splicing of CD33 Is Regulated by the HNRNPA Family Proteins.0
370815612023CD33 as a leukocyte-associated marker expressed on human spermatozoa.1
374791762023CD33 polymorphisms and Parkinson's disease Parkinson's disease in northern Chinese Han population: A case-control study.0
375065572023Plasma proteomic profiling identifies CD33 as a marker of HIV control in natural infection and after therapeutic vaccination.1
375191832023Lack of Association between CD33 rs3865444 and Amyotrophic Lateral Sclerosis: A Case-Control Study.0
351236182022[The Relationship between the Expressions of CD33 and CD13 and the Prognosis of Patients with Multiple Myeloma].0
354089902022CD33 rs2455069 SNP: Correlation with Alzheimer's Disease and Hypothesis of Functional Role.7
360513602022No Evidence that CD33 rs12459419 Polymorphism Predicts Gemtuzumab Ozogamicin Response in Consolidation Treatment of Acute Myeloid Leukemia Patients: Experience of the PETHEMA Group.0

Citation

Dessen P

CD33 (CD33 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/974/js/lib/css/haematological-explorer/