CD36 (CD36 molecule)

2003-11-01  

Identity

HGNC
CD36
LOCATION
7q21.11
LOCUSID
948
ALIAS
BDPLT10,CHDS7,FAT,GP3B,GP4,GPIV,PASIV,SCARB3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 948
MIM: 173510
HGNC: 1663
Ensembl: ENSG00000135218

Variants:

dbSNP: 948
ClinVar: 948
TCGA: ENSG00000135218
COSMIC: CD36

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135218ENST00000309881P16671
ENSG00000135218ENST00000309881A4D1B1
ENSG00000135218ENST00000394788P16671
ENSG00000135218ENST00000394788A4D1B1
ENSG00000135218ENST00000413265E7EX47
ENSG00000135218ENST00000419819E7EU05
ENSG00000135218ENST00000426978E7EWI4
ENSG00000135218ENST00000428497E9PC45
ENSG00000135218ENST00000432207P16671
ENSG00000135218ENST00000432207A4D1B1
ENSG00000135218ENST00000433696P16671
ENSG00000135218ENST00000435819P16671
ENSG00000135218ENST00000435819A4D1B1
ENSG00000135218ENST00000436384E9PC45
ENSG00000135218ENST00000438020E7ERZ9
ENSG00000135218ENST00000441034E7EVU1
ENSG00000135218ENST00000447544P16671
ENSG00000135218ENST00000447544A4D1B1
ENSG00000135218ENST00000482059E9PJX8
ENSG00000135218ENST00000488048H0YEE7
ENSG00000135218ENST00000534394E9PLT1
ENSG00000135218ENST00000538969P16671
ENSG00000135218ENST00000544133P16671

Expression (GTEx)

0
100
200
300
400
500
600
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PPAR signaling pathwayKEGGko03320
ECM-receptor interactionKEGGko04512
Hematopoietic cell lineageKEGGko04640
Adipocytokine signaling pathwayKEGGko04920
PPAR signaling pathwayKEGGhsa03320
ECM-receptor interactionKEGGhsa04512
Hematopoietic cell lineageKEGGhsa04640
Adipocytokine signaling pathwayKEGGhsa04920
MalariaKEGGko05144
MalariaKEGGhsa05144
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
DiseaseREACTOMER-HSA-1643685
Diseases of Immune SystemREACTOMER-HSA-5260271
Diseases associated with the TLR signaling cascadeREACTOMER-HSA-5602358
IRAK4 deficiency (TLR2/4)REACTOMER-HSA-5603041
MyD88 deficiency (TLR2/4)REACTOMER-HSA-5602498
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
Cross-presentation of particulate exogenous antigens (phagosomes)REACTOMER-HSA-1236973
ER-Phagosome pathwayREACTOMER-HSA-1236974
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Vesicle-mediated transportREACTOMER-HSA-5653656
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging by Class B ReceptorsREACTOMER-HSA-3000471
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340
Insulin resistanceKEGGhsa04931
Regulation of TLR by endogenous ligandREACTOMER-HSA-5686938
Neutrophil degranulationREACTOMER-HSA-6798695
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA26716COL3A1GenePathwayassociated20938371
PA26717COL4A1GenePathwayassociated20938371
PA26718COL4A2GenePathwayassociated20938371
PA33384PLCB1GenePathwayassociated20938371
PA33393PLCG2GenePathwayassociated20938371
PA35041COL1A1GenePathwayassociated20938371
PA35042COL1A2GenePathwayassociated20938371

References

Pubmed IDYearTitleCitations
362745892024CD36 polymorphism, sugary drinks, and sedentarism are associated with hypertriglyceridemic waist phenotype.1
383019892024Cancer-associated fibroblasts contributed to hepatocellular carcinoma recurrence and metastasis via CD36-mediated fatty-acid metabolic reprogramming.2
383204552024SELENOK-dependent CD36 palmitoylation regulates microglial functions and Aβ phagocytosis.0
386743542024Genotypic and Allelic Distribution of the CD36 rs1761667 Polymorphism in High-Level Moroccan Athletes: A Pilot Study.0
362745892024CD36 polymorphism, sugary drinks, and sedentarism are associated with hypertriglyceridemic waist phenotype.1
383019892024Cancer-associated fibroblasts contributed to hepatocellular carcinoma recurrence and metastasis via CD36-mediated fatty-acid metabolic reprogramming.2
383204552024SELENOK-dependent CD36 palmitoylation regulates microglial functions and Aβ phagocytosis.0
386743542024Genotypic and Allelic Distribution of the CD36 rs1761667 Polymorphism in High-Level Moroccan Athletes: A Pilot Study.0
356659292023New evidence of genetic heterogeneity causing hereditary gingival fibromatosis and ALK and CD36 as new candidate genes.2
367503212023Ferroptosis, Acyl Starvation, and Breast Cancer.3
367596762023CD36 neutralisation blunts TLR2-IRF7 but not IRF3 pathway in neonatal mouse brain and immature human microglia following innate immune challenge.1
367811532023Increased Platelet Activation demonstrated by Elevated CD36 and P-Selectin Expression in 1-Year Post-Recovered COVID-19 Patients.2
369275432023The cluster of differentiation 36 (CD36) rs1761667 polymorphism interacts with dietary patterns to affect cardiometabolic risk factors and metabolic syndrome risk in apparently healthy individuals.2
372712502023TM6SF2 reduces lipid accumulation in vascular smooth muscle cells by inhibiting LOX-1 and CD36 expression.0
373103962023Farnesyl diphosphate synthase exacerbates nonalcoholic steatohepatitis via the activation of AHR-CD36 axis.1

Citation

Dessen P

CD36 (CD36 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/976