Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 965
MIM: 153420
HGNC: 1688
Ensembl: ENSG00000116815
Variants:
dbSNP: 965
ClinVar: 965
TCGA: ENSG00000116815
COSMIC: CD58
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA444987 | Multiple Sclerosis | Disease | ClinicalAnnotation | associated | PD | ||
| PA450037 | interferon beta-1a | Chemical | ClinicalAnnotation | associated | PD | ||
| PA450039 | interferon beta-1b | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37994973 | 2024 | rs10924104 in the expression enhancer motif of CD58 confers susceptibility to human autoimmune diseases. | 2 |
| 38082156 | 2024 | From patient tissue correlates to molecular mechanisms of cancer immune evasion: the emerging role of CD58 and PD-L1 co-regulation via CMTM6. | 0 |
| 38176285 | 2024 | Association of CD58 rs12044852 and rs2300747 polymorphisms with the risk of multiple sclerosis: A systematic review and meta-analysis. | 0 |
| 37994973 | 2024 | rs10924104 in the expression enhancer motif of CD58 confers susceptibility to human autoimmune diseases. | 2 |
| 38082156 | 2024 | From patient tissue correlates to molecular mechanisms of cancer immune evasion: the emerging role of CD58 and PD-L1 co-regulation via CMTM6. | 0 |
| 38176285 | 2024 | Association of CD58 rs12044852 and rs2300747 polymorphisms with the risk of multiple sclerosis: A systematic review and meta-analysis. | 0 |
| 37573318 | 2023 | CD58 acts as a tumor promotor in hepatocellular carcinoma via activating the AKT/GSK-3β/β-catenin pathway. | 3 |
| 37904707 | 2023 | The CD2-CD58 axis: A novel marker predicting poor prognosis in patients with low-grade gliomas and potential therapeutic approaches. | 1 |
| 37573318 | 2023 | CD58 acts as a tumor promotor in hepatocellular carcinoma via activating the AKT/GSK-3β/β-catenin pathway. | 3 |
| 37904707 | 2023 | The CD2-CD58 axis: A novel marker predicting poor prognosis in patients with low-grade gliomas and potential therapeutic approaches. | 1 |
| 35881486 | 2022 | Multidimensional single-cell analysis identifies a role for CD2-CD58 interactions in clinical antitumor T cell responses. | 14 |
| 36288878 | 2022 | High Expression of CD58 and ALDH1A3 Predicts a Poor Prognosis in Basal-like Breast Cancer. | 5 |
| 35881486 | 2022 | Multidimensional single-cell analysis identifies a role for CD2-CD58 interactions in clinical antitumor T cell responses. | 14 |
| 36288878 | 2022 | High Expression of CD58 and ALDH1A3 Predicts a Poor Prognosis in Basal-like Breast Cancer. | 5 |
| 33649592 | 2021 | Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion. | 68 |
Citation
Dessen P
CD58 (CD58 molecule)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/984/cd58
