+9 or trisomy 9

2006-09-01   Ulrike Bacher , Claudia Haferlach 

1.Department for Internal Medicine III, Klinikum Grosshadern, Ludwig-Maximilians-University, Marchioninistr. 15, D-81377 Munich, Germany

Clinics and Pathology

Disease

B-lineage acute lymphoblastic leukemia

Epidemiology

Rare in Philadelphia-positive and in Philadelphia-negative B-lineage.

Cytogenetics

Additional anomalies: Philadelphia-negative ALL: Occurrence in hyperdiploid karyotypes (equal or more than 47 chromosomes) mostly in combination with other numerical gains. Philadelphia-positive ALL: Rare additional change.

Genes

Not known.

Prognosis

Philadelphia-negative ALL with high hyperdiploid karyotype (equal or more than 51 chromosomes) shows a good prognosis, gain of chromosome 9 is not typical and prognostic impact of trisomy 9 in this setting unknown. In Philadelphia-positive ALL additional chromosomal anomalies probably enhance the inferior prognosis.

Disease

T-lineage acute lymphoblastic leukemia.

Epidemiology

Rare, up to 4% in childhood T-ALL.

Cytogenetics

Additional anomalies: Occurs as sole or as combined anomaly.

Genes

Not known.

Prognosis

So far a prognostic impact could not be defined, which also might be due to the low analyzed case numbers.

Cytogenetics

Atlas Image
+9 (chromosome painting, WCP#9 (red))

Bibliography

Pubmed IDLast YearTitleAuthors
156928382005Conventional cytogenetics of myeloproliferative diseases other than CML contribute valid information.Bacher U et al
115039562001Chromosome and molecular abnormalities in myelodysplastic syndromes.Fenaux P et al
37085521986Numerical chromosome aberrations in human neoplasia.Heim S et al
20139801991Karyotypic patterns in chronic myeloproliferative disorders: report on 74 cases and review of the literature.Mertens F et al
124061012002Exploring polycythaemia vera with fluorescence in situ hybridization: additional cryptic 9p is the most frequent abnormality detected.Najfeld V et al
89820451996Prognostic significance of additional chromosome abnormalities in adult patients with Philadelphia chromosome positive acute lymphoblastic leukaemia.Rieder H et al
110019092000New recurring cytogenetic abnormalities and association of blast cell karyotypes with prognosis in childhood T-cell acute lymphoblastic leukemia: a pediatric oncology group report of 343 cases.Schneider NR et al

Summary

Note

Occurs in a large spectrum of myeloid and lymphatic malignancies - chronic myeloproliferative disorders (CMPD), acute myeloid leukemias (AML), myelodysplastic syndromes (MDS), acute lymphoblastic leukemias (ALL) of B-lineage and of T-lineage. Strong association to the CMPD and especially to polycythemia vera (PV).
Atlas Image
+9 (G-banding)

Citation

Ulrike Bacher ; Claudia Haferlach

+9 or trisomy 9

Atlas Genet Cytogenet Oncol Haematol. 2006-09-01

Online version: http://atlasgeneticsoncology.org/haematological/1020/tri9id1020

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