12p abnormalities in myeloid malignancies
1998-05-01 Chrystele Bilhou-Nabera Affiliation1.Cytogénétique,Laboratoire dHématologie-Pr RAPHAEL, Pav BROCA - 4me étage, 78 rue du Général Leclerc, 94275 LE KREMLIN-BICETRE, France
Clinics and Pathology
Epidemiology
12p abnormalities are common in a broad spectrum of haematological malignancies (acute lymphoblastic (ALL) or acute myeloid (AML) leukaemias, myelodysplastic (MDS) or chronic myeloproliferative syndromes, non-Hodgkins lymphomas; observed in about 5% of acute myeloid leukaemias and myelodysplastic syndromes; characteristic of secondary leukaemia after prior mutagenic exposure (10%) and associated with a poor prognosis (karyotypes mostly complex)
Genes Involved and Proteins
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9529134 | 1998 | Fluorescence in situ hybridization analyses of hematologic malignancies reveal frequent cytogenetically unrecognized 12p rearrangements. | Andreasson P et al |
| 7731705 | 1995 | Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. | Buijs A et al |
| 8168137 | 1994 | Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. | Golub TR et al |
| 8695816 | 1996 | Fluorescence in situ hybridization analysis of t(3; 12)(q26; p13): a recurring chromosomal abnormality involving the TEL gene (ETV6) in myelodysplastic syndromes. | Raynaud SD et al |
| 7632960 | 1995 | TEL and KIP1 define the smallest region of deletions on 12p13 in hematopoietic malignancies. | Sato Y et al |
| 9504635 | 1998 | Correlation of cytogenetic, molecular cytogenetic, and clinical findings in 59 patients with ANLL or MDS and abnormalities of the short arm of chromosome 12. | Streubel B et al |
| 9454771 | 1998 | Fluorescence in situ hybridization characterization of new translocations involving TEL (ETV6) in a wide spectrum of hematologic malignancies. | Wlodarska I et al |
Summary
del(12p) Partial karyotypes with 12p deletions (A); G- banding: seven left u2013 Courtesy Adriana Zamecnikova; following two - Courtesy Jean-Luc Lai and Alain Vanderhaegen; following: R- banding - Courtesy Jean-Luc Lai and (following ) Jean Loup Huret. Hybridization with LSI ETV6 break apart probe (Abbott molecular, US) showing deletion of the gene in metaphase and interphase cells (B,C). Partial ETV6 deletion as a result of del(12)(p13). u2013 Courtesy Adriana Zamecnikova.
Citation
Chrystele Bilhou-Nabera
12p abnormalities in myeloid malignancies
Atlas Genet Cytogenet Oncol Haematol. 1998-05-01
Online version: http://atlasgeneticsoncology.org/haematological/1032/12p-abnormalities-in-myeloid-malignancies
