12p abnormalities in myeloid malignancies

1998-05-01   Chrystele Bilhou-Nabera 

1.Cytogénétique,Laboratoire dHématologie-Pr RAPHAEL, Pav BROCA - 4me étage, 78 rue du Général Leclerc, 94275 LE KREMLIN-BICETRE, France

Clinics and Pathology


12p abnormalities are common in a broad spectrum of haematological malignancies (acute lymphoblastic (ALL) or acute myeloid (AML) leukaemias, myelodysplastic (MDS) or chronic myeloproliferative syndromes, non-Hodgkins lymphomas; observed in about 5% of acute myeloid leukaemias and myelodysplastic syndromes; characteristic of secondary leukaemia after prior mutagenic exposure (10%) and associated with a poor prognosis (karyotypes mostly complex)


Pubmed IDLast YearTitleAuthors
95291341998Fluorescence in situ hybridization analyses of hematologic malignancies reveal frequent cytogenetically unrecognized 12p rearrangements.Andreasson P et al
77317051995Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11.Buijs A et al
81681371994Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation.Golub TR et al
86958161996Fluorescence in situ hybridization analysis of t(3; 12)(q26; p13): a recurring chromosomal abnormality involving the TEL gene (ETV6) in myelodysplastic syndromes.Raynaud SD et al
76329601995TEL and KIP1 define the smallest region of deletions on 12p13 in hematopoietic malignancies.Sato Y et al
95046351998Correlation of cytogenetic, molecular cytogenetic, and clinical findings in 59 patients with ANLL or MDS and abnormalities of the short arm of chromosome 12.Streubel B et al
94547711998Fluorescence in situ hybridization characterization of new translocations involving TEL (ETV6) in a wide spectrum of hematologic malignancies.Wlodarska I et al


Atlas Image
del(12p)  Partial karyotypes with 12p deletions (A); G- banding: seven left u2013 Courtesy Adriana Zamecnikova; following two - Courtesy Jean-Luc Lai and Alain Vanderhaegen; following: R- banding - Courtesy Jean-Luc Lai and (following ) Jean Loup Huret. Hybridization with LSI ETV6 break apart probe (Abbott molecular, US) showing deletion of the gene in metaphase and interphase cells (B,C). Partial ETV6 deletion as a result of del(12)(p13). u2013 Courtesy Adriana Zamecnikova.


Chrystele Bilhou-Nabera

12p abnormalities in myeloid malignancies

Atlas Genet Cytogenet Oncol Haematol. 1998-05-01

Online version: http://atlasgeneticsoncology.org/haematological/1032/12p-abnormalities-in-myeloid-malignancies

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