+14 or trisomy 14 (solely)

1997-08-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


myeloid disorders: MDS in more than half cases, AML in 1/4 ofcases, chronic myeloproliferative syndrome (atypical CML); exceptionally:lymphoproliferations; therefore, only trisomy 14 solely in myeloidmalignanies is herein described

Phenotype stem cell origin

MDS: RA, RAEB±T mainly; AML: M1, M2, M4;atypical CML: with dysplastic features


median age 60-65 yrs (range: 4-89 yrs); sex ratio: 4M/3F


no history of carcinogen exposure of note; blood data: plateletscount: 130 X 109/l; monocytosis in half cases


all FAB subtypes of MDS can be found; atypical CMLcases present with dysplastic features; non-lobulated megakaryocytes areoften found


survival < 2yrs in most cases; +14 do not seem to bear a distinctprognosis


Cytogenetics morphological

most often (90% of cases) in mosaic with normal cells

Cytogenetics molecular

chromosome painting (although +14 detection attemptsare, so far, not relevant)

Additional anomalies

none, at least in the sub-clone with +14 solely, bythat very fact; most often none in karyotype follow-up


may be found as i(14q)

Genes Involved and Proteins

genes involved are unknown


Pubmed IDLast YearTitleAuthors
16254801992Four additional cases of trisomy 14 as the sole anomaly in various haematological malignancies.Brizard A et al
92335821997Trisomy 14 is a non-random karyotypic abnormality associated with myeloid malignancies.Toze CL et al


Jean-Loup Huret

+14 or trisomy 14 (solely)

Atlas Genet Cytogenet Oncol Haematol. 1997-08-01

Online version: http://atlasgeneticsoncology.org/haematological/1034/+14-or-trisomy-14-(solely)