+14 or trisomy 14 (solely)

1997-08-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

myeloid disorders: MDS in more than half cases, AML in 1/4 ofcases, chronic myeloproliferative syndrome (atypical CML); exceptionally:lymphoproliferations; therefore, only trisomy 14 solely in myeloidmalignanies is herein described

Phenotype stem cell origin

MDS: RA, RAEB±T mainly; AML: M1, M2, M4;atypical CML: with dysplastic features

Epidemiology

median age 60-65 yrs (range: 4-89 yrs); sex ratio: 4M/3F

Clinics

no history of carcinogen exposure of note; blood data: plateletscount: 130 X 109/l; monocytosis in half cases

Cytology

all FAB subtypes of MDS can be found; atypical CMLcases present with dysplastic features; non-lobulated megakaryocytes areoften found

Prognosis

survival < 2yrs in most cases; +14 do not seem to bear a distinctprognosis

Cytogenetics

Cytogenetics morphological

most often (90% of cases) in mosaic with normal cells

Cytogenetics molecular

chromosome painting (although +14 detection attemptsare, so far, not relevant)

Additional anomalies

none, at least in the sub-clone with +14 solely, bythat very fact; most often none in karyotype follow-up

Variants

may be found as i(14q)

Genes Involved and Proteins

Note
genes involved are unknown

Bibliography

Pubmed IDLast YearTitleAuthors
16254801992Four additional cases of trisomy 14 as the sole anomaly in various haematological malignancies.Brizard A et al
92335821997Trisomy 14 is a non-random karyotypic abnormality associated with myeloid malignancies.Toze CL et al

Citation

Jean-Loup Huret

+14 or trisomy 14 (solely)

Atlas Genet Cytogenet Oncol Haematol. 1997-08-01

Online version: http://atlasgeneticsoncology.org/haematological/1034/+14-or-trisomy-14-(solely)

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