+14 or trisomy 14 (solely)
1997-08-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
myeloid disorders: MDS in more than half cases, AML in 1/4 ofcases, chronic myeloproliferative syndrome (atypical CML); exceptionally:lymphoproliferations; therefore, only trisomy 14 solely in myeloidmalignanies is herein described
Phenotype stem cell origin
MDS: RA, RAEB±T mainly; AML: M1, M2, M4;atypical CML: with dysplastic features
Epidemiology
median age 60-65 yrs (range: 4-89 yrs); sex ratio: 4M/3F
Clinics
no history of carcinogen exposure of note; blood data: plateletscount: 130 X 109/l; monocytosis in half cases
Cytology
all FAB subtypes of MDS can be found; atypical CMLcases present with dysplastic features; non-lobulated megakaryocytes areoften found
Prognosis
survival < 2yrs in most cases; +14 do not seem to bear a distinctprognosis
Cytogenetics
Cytogenetics morphological
most often (90% of cases) in mosaic with normal cells
Cytogenetics molecular
chromosome painting (although +14 detection attemptsare, so far, not relevant)
Additional anomalies
none, at least in the sub-clone with +14 solely, bythat very fact; most often none in karyotype follow-up
Variants
may be found as i(14q)
Genes Involved and Proteins
Note
genes involved are unknown
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 1625480 | 1992 | Four additional cases of trisomy 14 as the sole anomaly in various haematological malignancies. | Brizard A et al |
| 9233582 | 1997 | Trisomy 14 is a non-random karyotypic abnormality associated with myeloid malignancies. | Toze CL et al |
Citation
Jean-Loup Huret
+14 or trisomy 14 (solely)
Atlas Genet Cytogenet Oncol Haematol. 1997-08-01
Online version: http://atlasgeneticsoncology.org/haematological/1034/+14-or-trisomy-14-(solely)
