M0 acute myeloid leukemia (M0-AML)

2002-05-01   Marie Christine Bene 

1.Laboratoire dImmunologie du CHU, Faculté de Médecine de Nancy, BP 184, 54500 Vandoeuvre les Nancy, France
2.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


rare: 3 - 5 % of AML; med age 45 yrs; 20% are children; unbalanced sex ratio in the adults: 1.6 M/1F, p< 0.01


High WBC mostly in children; frequently low Hb and platelets; organomegaly in children


Undifferentiated blasts, cytochemistry: negative for myeloperoxydase. Positivity of at least one myeloid marker (CD13, CD33, CD65, CD117-c-KIT). Frequent expression of early progenitor markers CD34, DR; TdT in 30-40% of the cases; CD7 expression frequent in children. MPO antigen identified in about 50% of the cases.


Poor: CR in 50% of cases, med survival: 8 mths Poor prognosis factors: older age, high WBC, low platelets, CD10, CD14, CD15.

Highly cited references

Pubmed IDYearTitleCitations
357388722022A montane species treeline is defined by both temperature and drought effects on growth season length.0
357385602022Global REACH 2018: increased adrenergic restraint of blood flow preserves coupling of oxygen delivery and demand during exercise at high-altitude.0
357385262022Evaluation of Morphological Variations of Petrotympanic Fissure Using Computed Tomography Imaging of the Temporal Bone.0
357382282022Clinical and economic burden of uncontrolled severe noneosinophilic asthma.0
357379642022Microbial and Environmental Processes Shape the Link between Organic Matter Functional Traits and Composition.0
357378542022Dinuclear Fluoride Single-Bridged Lanthanoid Complexes as Molecule Magnets: Unprecedented Coupling Constant in a Fluoride-Bridged Gadolinium Compound.0
357367442022Nutrient Composition Analysis of Maize Hybrids Affected by Different Nitrogen Fertilisation Systems.0
357367082022Phenotypic Differences and Physiological Responses of Salt Resistance of Walnut with Four Rootstock Types.0
357366602022A Prospective Study of Medication Surveillance of a Pediatric Tertiary Care Hospital in Lahore, Pakistan.0
357363252022Palladium Membrane with High Density of Large-Angle Grain Boundaries to Promote Hydrogen Diffusivity.0
357363012022Fabrication and Characterization of Orodispersible Composite Film from Hydroxypropylmethyl Cellulose-Crosslinked Carboxymethyl Rice Starch.0
357361352022Comparative Analysis of Mononuclear 1:1 and 2:1 Tetravalent Actinide (U, Th, Np) Complexes: Crystal Structure, Spectroscopy, and Electrochemistry.0
357359892022Delayed Concentration Effect Models for Dabigatran Anticoagulation.0
357358872022Seasonal and Year-Round Distributions of Bactrocera dorsalis (Hendel) and Its Risk to Temperate Fruits under Climate Change.0
357358772022A LAMP Assay for the Detection of Thecodiplosis japonensis, an Alien Gall Midge Species Pest of Pine Trees.0
357355692022A High-Throughput MEMS-Based Differential Scanning Calorimeter for Direct Thermal Characterization of Antibodies.0
357355372022A Novel Prototype Biosensor Array Electrode System for Detecting the Bacterial Pathogen Salmonella typhimurium.0
357349222022Selective Ru Adsorption on SnO2/CeO2 Mixed Oxides for Efficient Destruction of Multicomponent Volatile Organic Compounds: From Laboratory to Practical Possibility.0
357343762022Association of Recent and Long-Term Supplement Intakes With Laboratory Indices in Patients With COVID-19 in Tehran, Iran, During 2020.0
357342602022Suitable Fertilizer Application Depth Enhances the Efficient Utilization of Key Resources and Improves Crop Productivity in Rainfed Farmland on the Loess Plateau, China.0
357340202022Experimental data on developmental elimination of retrosplenial cortex GABAergic interneurons in a mouse model of ethanol exposure during the last trimester of human pregnancy.0
357338012022"You Want Them Pretty, but Not Too Intelligent!": Everyday Talk and the Continuum of Men's Violence Against Women in Forensic Institutional Care.0
357334182022Current Status, Opportunities, and Challenges of Exosomes in Oral Cancer Diagnosis and Treatment.0
357324802022Refractory Psychosis After Carbon Monoxide Poisoning: a Case Report.0
357319942022Constructing Unique Mesoporous Carbon Superstructures via Monomicelle Interface Confined Assembly.0
357316452022A Task-Specific Algorithm to Estimate Occupational (1→3)-β-D-glucan Exposure for Farmers in the Biomarkers of Exposure and Effect in Agriculture Study.0
357308972022Chronic oil spills revealed by the most important set of samples from the incident in northeastern Brazil, 2019.0
357307532022The cross-interface energy-filtering effect at organic/inorganic interfaces balances the trade-off between thermopower and conductivity.0
357307372022Aerosol Hygroscopicity and its Link to Chemical Composition in a Remote Marine Environment Based on Three Transatlantic Measurements.0
357304792022Review of Tralokinumab in the Treatment of Atopic Dermatitis.0
357289012022Indirect impacts of the COVID-19 pandemic at two tertiary neonatal units in Zimbabwe and Malawi: an interrupted time series analysis.0
357286132022Gingival Mesenchymal Stem Cells Metabolite Decreasing TRAP, NFATc1, and Sclerostin Expression in LPS-Associated Inflammatory Osteolysis In Vivo.0
357279162022Tixagevimab/cilgavimab pre-exposure prophylaxis is associated with lower breakthrough infection risk in vaccinated solid organ transplant recipients during the Omicron wave.0
357275862022Time Course for Benefit and Risk With Ticagrelor and Aspirin in Individuals With Acute Ischemic Stroke or Transient Ischemic Attack Who Carry CYP2C19 Loss-of-Function Alleles: A Secondary Analysis of the CHANCE-2 Randomized Clinical Trial.0
357275802022Efficacy and Safety of Varenicline for Smoking Cessation in Patients With Type 2 Diabetes: A Randomized Clinical Trial.0
357273742022Prevalence and predictors of psychological distress among patients with thyroid cancer during transitional period in China: a cross-sectional study.0
357273142022Thermochemical Cyclization Constructs Bridged Dual-Coating of Ni-Rich Layered Oxide Cathodes for High-Energy Li-Ion Batteries.0
357270652022Virtual arthroplasty clinic: a single centre experience: commentary on progress, cost savings and patient retention.0
357264392022High-stretchability, Ultralow-hysteresis Conducting Polymer Hydrogel Strain Sensors for Soft Machines.0
357259272022Continuous cuffless monitoring of arterial blood pressure via graphene bioimpedance tattoos.0
357258952022Efficient biodiesel production from oleic and palmitic acid using a novel molybdenum metal-organic framework as efficient and reusable catalyst.0
357158012022Safety and efficacy of the Seraph® 100 Microbind® Affinity Blood Filter to remove bacteria from the blood stream: results of the first in human study.0
357157812022Highly efficient magnetic ablation and the contrast of various imaging using biocompatible liquid-metal gallium.0
357250242022A Psychometric Appraisal of the Motivated Strategies for Learning Questionnaire (MSLQ) in Final Year Undergraduate Nursing Students.0
357247582022Pelvic floor symptoms from first pregnancy up to 8 years after the first delivery: a longitudinal study.0
357238532022Hepatorenal Toxicity of Inorganic Arsenic in White Pekin Ducks and Its Amelioration by Using Ginger.0
357238262022Dissipation and risk assessment of fluopyram and trifloxystrobin on onion by GC-MS/MS.0
357236222022A retrospective cohort study: pre-operative oral enteral nutritional optimisation for Crohn's disease in a UK tertiary IBD Centre.0
357234622022Preparation of Human Myocardial Tissue for Long-term Cultivation.0
357221562022Stachys pilifera Benth: A Review of Its Botany, Phytochemistry, Therapeutic Potential, and Toxicology.0
357217602022The Effect of Early Life Exposure to Triclosan on Thyroid Follicles and Hormone Levels in Zebrafish.0
357215842022Longitudinal Shifts of Solid Tumor and Liquid Biopsy Sequencing Concordance in Metastatic Breast Cancer.0
357212292022Visual Outcomes of Microkeratome-Assisted Anterior Lamellar Keratoplasty in Keratoconus: 5-Year Results.0
357208442022Phenotypic and Molecular Characterization of Bovine Mastitis Milk Origin Bacteria and Linkage of Intramammary Infection With Milk Quality.0
357208402022Tracking Infection and Genetic Divergence of Methicillin-Resistant Staphylococcus aureus at Pets, Pet Owners, and Environment Interface.0
357201192022Membrane Lipids in the Thyroid Comparing to Those in Non-Endocrine Tissues Are Less Sensitive to Pro-Oxidative Effects of Fenton Reaction Substrates.0
357190562022A prospective, single-center, randomized clinical trial to evaluate the efficacy of three types of laser vaporization surgeries using a 180-W GreenLight XPS laser, a 300-W diode laser, and a 200-W thulium laser for the treatment of benign prostatic hyperplasia.0
357188792022One-Step Thermal Gradient- and Antisolvent-Free Crystallization of All-Inorganic Perovskites for Highly Efficient and Thermally Stable Solar Cells.0
357178172022Clays play a catalytic role in pyrolytic treatment of crude-oil contaminated soils that is enhanced by ion-exchanged transition metals.0
357176322022Exogenous melatonin enhances soybean (glycine max (l.) merr.) seedling tolerance to saline-alkali stress by regulating antioxidant response and DNA damage repair.0
357174442022Efficacy and safety of radiofrequency ablation versus parathyroidectomy for secondary hyperparathyroidism in dialysis patients: a single-center retrospective study.0
357169902022Azilsartan-nicotinamide cocrystal: Preparation, characterization and in vitro / vivo evaluation.0
357168582022Testosterone does not shorten action potential duration in Langendorff perfused rabbit ventricles.0
357166922022Safety and efficacy of eptinezumab for migraine prevention in patients with two-to-four previous preventive treatment failures (DELIVER): a multi-arm, randomised, double-blind, placebo-controlled, phase 3b trial.0
357163012022Efficient removal of antibiotics from water resourcchenes is a public health priority: a critical assessment of the efficacy of some remediation strategies for antibiotics in water.0
357161782022Effects of sugar concentration on the electroporation, size distribution and average size of charged giant unilamellar vesicles.0
357147452022Stream bacterial diversity peaks at intermediate freshwater salinity and varies by salt type.0
357139742022Short-term and Long-term Outcomes of Laparoscopic Versus Open Selective Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer: Results of a Multicenter Lateral Node Study in China.0
357138732022Efficacy and Safety of Insulin Glargine 300 U/mL in People with Type 2 Diabetes Uncontrolled on Basal Insulin: The 26-Week Interventional, Single-Arm ARTEMIS-DM Study.0
357136352022Enhanced Basicity of MnOx Supported Ru for the Selective Oxidation of HMF to FDCA.0
357130102022Molecular epidemiology and genotype-specific disease severity of hepatitis E virus infections in Germany, 2010-2019.0
357129222022[Clinical study on real-time three-dimensional CT navigation-guided full-endoscopic lumbar interbody fusion].0
357128502022The psychometric properties of the of the Persian version of the Screen for adult anxiety related disorders (SCAARED) in patients with anxiety disorders.0
357122322022Font Design in Visual Communication Design of Genetic Algorithm.0
357106782022A large, curated, open-source stroke neuroimaging dataset to improve lesion segmentation algorithms.0
357059662022Data quality and associated factors in the health management information system at health centers in Shashogo district, Hadiya zone, southern Ethiopia, 2021.0
357058902022Surgical Ablation of Cardiac Tissue with Nanosecond Pulsed Electric Fields in Swine.0
357056672022Elevated light intensity compensates for nitrogen deficiency during chrysanthemum growth by improving water and nitrogen use efficiency.0
357055012022Long-Term Efficacy and Safety From an Open-Label Extension of Adjunctive Cenobamate in Patients With Uncontrolled Focal Seizures.0
357054972022Preferences and User Experiences of Wearable Devices in Epilepsy: A Systematic Review and Mixed-Methods Synthesis.0
357095282022Excellent Medium-Temperature Thermoelectric Performance of Monolayer BiOCl.0
357095092022Efficacy of a Novel Injection Lipolysis to Induce Targeted Adipocyte Apoptosis: A Randomized, Phase IIa Study of CBL-514 Injection on Abdominal Subcutaneous Fat Reduction.0
357092082022Determination of the optimal working performance matching through theoretical analysis and experimental study for a screw conveyor.0
357090432022Nonlinearity-aware PS-PAM-16 transmission for C-band net-300-Gbit/s/λ short-reach optical interconnects with a single DAC.0
357083592022Comparison of specimen quality among the standard suction, slow-pull, and wet suction techniques for EUS-FNA: A multicenter, prospective, randomized controlled trial.0
357073372022Prevention of catheter tip malposition with an ultrasound-guided finger-pressure method to block the internal jugular vein during PICC placement: a meta-analysis.0
357047892022Synergistic Manipulation of Interdependent Thermoelectric Parameters in SnTe-AgBiTe2 Alloys by Mn Doping.0
357045052022Antibody ratios against NS1 antigens of tick-borne encephalitis and West Nile viruses support differential flavivirus serology in dogs.0
357044752022Fat Grafting With Expanded Adipose-derived Stromal Cells for Breast Augmentation: A Randomized Controlled Trial.0
357043892022Trinuclear coordination assemblies of low-spin dicyano manganese(II) (S = 1/2) and iron(II) (S = 0) phthalocyanines with manganese(II) acetylacetonate, tris(cyclopentadienyl)gadolinium(III) and neodymium(III).0
357042282022TGF-β1 receptor blockade attenuates unilateral ureteral obstruction-induced renal fibrosis in C57BL/6 mice through attenuating Smad and MAPK pathways.0
357042122022Optimizing the Culture Medium of Lasiodiplodia sp. to Improve the Yield of Ethyl Acetate Extract as an Antimicrobial Source.0
357037072022Evaluation of irradiance and radiant exposure on the polymerization and mechanical properties of a resin composite.0
357036372022Chemical and physical features of biological fluids in treatment of hydatid disease.0
357032112022Soft Tissue Reconstruction for Upper Extremity Necrotizing Soft Tissue Infections.0
357031652022Selective and sensitive toxic gas-sensing mechanism in a 2D Janus MoSSe monolayer.0
357016062022Efficacy of synthetic surfactant (CHF5633) bolus and/or lavage in meconium-induced lung injury in ventilated newborn rabbits.0
357014542022Disruption of spatiotemporal clustering in dengue cases by wMel Wolbachia in Yogyakarta, Indonesia.0
357011152022[Curcumin alleviates the manganese-induced neurotoxicity by promoting autophagy in rat models of manganism].0
353306152022"We threw away the stones": a mixed method evaluation of a simple cookstove intervention in Malawi.0


Pubmed IDLast YearTitleAuthors
113804652001Acute myeloid leukaemia M0: haematological, immunophenotypic and cytogenetic characteristics and their prognostic significance: an analysis in 241 patients.Béné MC et al
105167511999The immunophenotype of minimally differentiated acute myeloid leukemia (AML-M0): reduced immunogenicity and high frequency of CD34+/CD38- leukemic progenitors.Costello R et al
103895941999AML-M0: a review of laboratory features and proposal of new diagnostic criteria.Stasi R et al



Stasis criteria
  • 30% blast cells in the bone marrow with <50% erythroblasts
  • Cytochemical staining MPO/SSB <3% of blasts
  • Cytochemical staining for PAS, AcP and NSE negative or weak
  • At least one of these three immunologic markers positive : MPO, CD13, CD33, in flow cytometry or ultrastructurally
  • Absence of cCD3, cCD22 and cCD79a
  • Citation

    Marie Christine Bene

    M0 acute myeloid leukemia (M0-AML)

    Atlas Genet Cytogenet Oncol Haematol. 2002-05-01

    Online version: http://atlasgeneticsoncology.org/haematological/1057/m0anllid1057

    Historical Card

    1999-12-01 M0 acute myeloid leukemia (M0-AML) by  Jean-Loup Huret 

    Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

    External Links