t(10;11)(p12;q21) PICALM/MLLT10

1998-01-01   Jean-Loup Huret , Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

a mainly T-cell ALL; at times AML and/or AML with T-cellcommon progenitor may be involved; FAB: L1/L2

Phenotype stem cell origin

a myelomonocytic/T- cell

Epidemiology

< 1% of ALL; about 5 % of T-ALL; sex ratio: 9M/5F (from 14 cases herein reviewed)

Clinics

organomegaly; no CNS involvement; blood data: high WBC (range 20-170 X 109/l)

Prognosis

median survival: 22 mths in this review; range: 0-33+ mths, n=11(but we are to be cautious: cases ascertained by molecular studies areneeded before true prognostic ascertainment)

Cytogenetics

Cytogenetics molecular

investigations are required

Additional anomalies

most often (11/15 cases) present; del(5q), +8, and +19already recurrent

Genes Involved and Proteins

Gene name
MLLT10 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10)
Location
10p12.31
Dna rna description
5 telomeric --> 3 centromeric orientation
Protein description
contains 3 Zn fingezrs and a leucine zipper; nuclearlocalisation; transcription factor
Gene name
PICALM (clathrin assembly lymphoid myeloid leukemia gene)
Location
11q14.2
Protein description
role in the integration of different signals;

Result of the Chromosomal Anomaly

Transcript

both 5 CALM - 3 AF10 and 5 AF10 - 3 CALM are expressed

Description

1- a 1595 amino acids protein with N-term and most of CALM(except the last 4 amino acids!) fused to most of AF10 from amino acid 81(excluding the N-term zinc finger of AF10) C-term; 2- and a small 84 aminoacids protein with N-term zinc finger from AF10 fused to the very C-termend of CALM

Oncogenesis

it is not known which of the 2 fusion protein has the critical role

Highly cited references

Pubmed IDYearTitleCitations
350822692022Clinico-biological features of T-cell acute lymphoblastic leukemia with fusion proteins.1
333175672020Detailed molecular cytogenetic characterisation of the myeloid cell line U937 reveals the fate of homologous chromosomes and shows that centromere capture is a feature of genome instability.1
317391262020Molecular and phenotypic characterization of an early T-cell precursor acute lymphoblastic lymphoma harboring PICALM-MLLT10 fusion with aberrant expression of B-cell antigens.3
334894532020Fatal hyperleukocytic T lymphoblastic lymphoma/leukemia complicated with multi-gene fusion and mutation: clinical revelation and perception.0
309147382019Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma.9
291895092018Successful Treatment of a Very Late Isolated Relapse in an Adolescent With a PICALM-MLLT10 Positive T-lineage Acute Lymphoblastic Leukemia.0
302273972018Mediastinal Myeloid Sarcoma with TP53 Mutation Preceding Acute Myeloid Leukemia with a PICALM-MLLT10 Fusion Gene.1
236738602013New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia.25
236702962013Detection of PICALM-MLLT10 (CALM-AF10) and outcome in children with T-lineage acute lymphoblastic leukemia.13
238319222013The prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest.19
228714732012PICALM-MLLT10 acute myeloid leukemia: a French cohort of 18 patients.13
222358512012EZH2 mutations and their association with PICALM-MLLT10 positive acute leukaemia.8
208758752010Acute leukemia with PICALM-MLLT10 fusion gene: diagnostic and treatment struggle.9
165188482006Acute monocytic leukemia with coexpression of minor BCR-ABL1 and PICALM-MLLT10 fusion genes along with overexpression of HOXA9.1
158438272005Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.23

Bibliography

No bibliography items were found for this article.

Summary

Fusion gene

PICALM/MLLT10 PICALM (11q14.2) MLLT10 (10p12.31) M t(10;11)(p12;q14) t(10;11)(p12;q23) t(10;19;11)(p12;p13;q14) t(9;11)(p12;q14)|PICALM/MLLT10 PICALM (11q14.2) MLLT10 (10p12.31) TF LAML|PICALM/MLLT10 PICALM (11q14.2) MLLT10 (10p12.31) TIC

Note

the description opf this rare entity is arduous, since cases without molecular studies can be confused with cases of t(10;11)(p12;q23)
Atlas Image
t(10;11)(p13;q21) G-banding (top 2) - Courtesy Diane H. Norback, Eric B. Johnson, Sara Morrison-Delap UW Cytogenetic Services; middle row: - Courtesy Catherine Roche-Lestienne. R-banding (bottom 2) and Fish studies with MLL probe showing a signal on the normal 11 and one on the der(10) (right) and with chromosome 11 paint - Courtesy Pascale Cornillet-Lefebvre and Stéphanie Struski.

Citation

Jean-Loup Huret ; Jean-Loup Huret

t(10;11)(p12;q21) PICALM/MLLT10

Atlas Genet Cytogenet Oncol Haematol. 1998-01-01

Online version: http://atlasgeneticsoncology.org/haematological/1067/t(10;11)(p12;q21)-picalm-mllt10

External Links