t(5;14)(q31;q32) IGH/IL3

1999-12-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

B-cell acute lymphoblastic leukemia (ALL) with hypereosinophilia

Phenotype stem cell origin

CD19+, CD10+ ALL; eosinophils are not part of the leukemic cells and do not carry the t(5;14); they represent a reactive population (eosinophilia in association with ALL is usually reactive)

Epidemiology

rarely described; 6M/1F; affects both children and adults, general features of ALL with hypereosinophilia are rarity, male predominance; and young age

Cytology

marked eosinophilia; basophilia; IL3 is over-expressed

Prognosis

prognosis appears to be poor, a feature of ALLs with hypereosinophilia

Genes Involved and Proteins

Gene name
IL3 (interleukin-3)
Location
5q31.1
Protein description
152 amino acids; growth factor; colony stimulating factor involved in the survival, proliferation and differentiation of multipotent hematopoietic cells
Gene name
IGH (Immunoglobulin Heavy)
Location
14q32.33

Result of the Chromosomal Anomaly

Description

break in the promoter region of IL3 and in the Jh region of IgH

Expression localisation

the immunoglobulin gene promoter controls the expression of IL3

Oncogenesis

over-expression of IL3

Highly cited references

Pubmed IDYearTitleCitations
319216382019B-ALL With t(5;14)(q31;q32); IGH-IL3 Rearrangement and Eosinophilia: A Comprehensive Analysis of a Peculiar IGH-Rearranged B-ALL.6

Bibliography

Pubmed IDLast YearTitleAuthors

Summary

Fusion gene

IGH/IL3 IGH (14q32.33) IL3 (5q31.1) M t(5;14)(q31;q32)
Atlas Image
t(5;14)(q31;q32) G- banding - Courtesy Melanie Zenger and Claudia Haferlach.

Citation

Jean-Loup Huret

t(5;14)(q31;q32) IGH/IL3

Atlas Genet Cytogenet Oncol Haematol. 1999-12-01

Online version: http://atlasgeneticsoncology.org/haematological/1111/css/template-nav.css