t(5;14)(q31;q32) IGH/IL3

1999-12-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

B-cell acute lymphoblastic leukemia (ALL) with hypereosinophilia

Phenotype stem cell origin

CD19+, CD10+ ALL; eosinophils are not part of the leukemic cells and do not carry the t(5;14); they represent a reactive population (eosinophilia in association with ALL is usually reactive)

Epidemiology

rarely described; 6M/1F; affects both children and adults, general features of ALL with hypereosinophilia are rarity, male predominance; and young age

Cytology

marked eosinophilia; basophilia; IL3 is over-expressed

Prognosis

prognosis appears to be poor, a feature of ALLs with hypereosinophilia

Genes Involved and Proteins

Gene name
IL3 (interleukin-3)
Location
5q31.1
Protein description
152 amino acids; growth factor; colony stimulating factor involved in the survival, proliferation and differentiation of multipotent hematopoietic cells
Gene name
IGH (Immunoglobulin Heavy)
Location
14q32.33

Result of the Chromosomal Anomaly

Description

break in the promoter region of IL3 and in the Jh region of IgH

Expression localisation

the immunoglobulin gene promoter controls the expression of IL3

Oncogenesis

over-expression of IL3

Bibliography

Pubmed IDLast YearTitleAuthors
25084001989Calla-positive acute leukaemia with t(5q;14q) translocation and hypereosinophilia--a unique entity?Baumgarten E et al
16384751992Non-random involvement of chromosome 5 in ALL.Chen Z et al
23745081990Acute lymphoblastic leukemia with eosinophilia.Fishel RS et al
24993621989The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene.Grimaldi JC et al
15649541992Cytogenetic analysis in relapsed childhood acute lymphoblastic leukemia.Heerema NA et al
35466151987Acute lymphoblastic leukemia with chromosomal 5;14 translocation and hypereosinophilia: case report and literature review.Hogan TF et al
75123641993Power of the MAC (morphology-antibody-chromosomes) method in distinguishing reactive and clonal cells: report of a patient with acute lymphatic leukemia, eosinophilia, and t(5;14).Knuutila S et al
34795321987Three-way reciprocal chromosomal translocation in an acute lymphoblastic leukemia patient with hypereosinophilia syndrome.McConnell TS et al
21149331990Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia.Meeker TC et al
65834691984Hypereosinophilic syndrome in acute lymphoblastic leukemia with a chromosome translocation [t(5q;14q)].Tono-oka T et al

Summary

Fusion gene

IGH/IL3 IGH (14q32.33) IL3 (5q31.1) M t(5;14)(q31;q32)
Atlas Image
t(5;14)(q31;q32) G- banding - Courtesy Melanie Zenger and Claudia Haferlach.

Citation

Jean-Loup Huret

t(5;14)(q31;q32) IGH/IL3

Atlas Genet Cytogenet Oncol Haematol. 1999-12-01

Online version: http://atlasgeneticsoncology.org/haematological/1111/t(5;14)(q31;q32)

External Links