t(5;14)(q31;q32) IGH/IL3

1999-12-01 Jean-Loup Huret Affiliation

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

B-cell acute lymphoblastic leukemia (ALL) with hypereosinophilia

Phenotype stem cell origin

CD19+, CD10+ ALL; eosinophils are not part of the leukemic cells and do not carry the t(5;14); they represent a reactive population (eosinophilia in association with ALL is usually reactive)

Epidemiology

rarely described; 6M/1F; affects both children and adults, general features of ALL with hypereosinophilia are rarity, male predominance; and young age

Cytology

marked eosinophilia; basophilia; IL3 is over-expressed

Prognosis

prognosis appears to be poor, a feature of ALLs with hypereosinophilia

Genes Involved and Proteins

Gene name

IL3 (interleukin-3)

Location

5q31.1

Protein description

152 amino acids; growth factor; colony stimulating factor involved in the survival, proliferation and differentiation of multipotent hematopoietic cells

Gene name

IGH (Immunoglobulin Heavy)

Location

14q32.33

Result of the Chromosomal Anomaly

Description

break in the promoter region of IL3 and in the Jh region of IgH

Expression localisation

the immunoglobulin gene promoter controls the expression of IL3

Oncogenesis

over-expression of IL3

Highly cited references

Pubmed ID	Year	Title	Citations
31921638	2019	B-ALL With t(5;14)(q31;q32); IGH-IL3 Rearrangement and Eosinophilia: A Comprehensive Analysis of a Peculiar IGH-Rearranged B-ALL.	6

Article Bibliography

Pubmed ID	Last Year	Title	Authors
2508400	1989	Calla-positive acute leukaemia with t(5q;14q) translocation and hypereosinophilia--a unique entity?	Baumgarten E et al
1638475	1992	Non-random involvement of chromosome 5 in ALL.	Chen Z et al
2374508	1990	Acute lymphoblastic leukemia with eosinophilia.	Fishel RS et al
2499362	1989	The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene.	Grimaldi JC et al
1564954	1992	Cytogenetic analysis in relapsed childhood acute lymphoblastic leukemia.	Heerema NA et al
3546615	1987	Acute lymphoblastic leukemia with chromosomal 5;14 translocation and hypereosinophilia: case report and literature review.	Hogan TF et al
7512364	1993	Power of the MAC (morphology-antibody-chromosomes) method in distinguishing reactive and clonal cells: report of a patient with acute lymphatic leukemia, eosinophilia, and t(5;14).	Knuutila S et al
3479532	1987	Three-way reciprocal chromosomal translocation in an acute lymphoblastic leukemia patient with hypereosinophilia syndrome.	McConnell TS et al
2114933	1990	Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia.	Meeker TC et al
6583469	1984	Hypereosinophilic syndrome in acute lymphoblastic leukemia with a chromosome translocation [t(5q;14q)].	Tono-oka T et al

Summary

Fusion gene

IGH/IL3 IGH (14q32.33) IL3 (5q31.1) M t(5;14)(q31;q32)

t(5;14)(q31;q32) G- banding - Courtesy Melanie Zenger and Claudia Haferlach.

Citation

Jean-Loup Huret

t(5;14)(q31;q32) IGH/IL3

Atlas Genet Cytogenet Oncol Haematol. 1999-12-01

Online version: http://atlasgeneticsoncology.org/haematological/1111/t(5;14)(q31;q32)