+15 or trisomy 15 (as sole autosomal abnormality)

1999-05-01   Elizabeth J Sinclair , Anthony M Potter 

1.Centre for Human Genetics, Sheffield, United Kingdom

Clinics and Pathology

Disease

myeloid and lymphoid lineages (myelodysplastic syndromes (MDS), acute nonlymphocytic leukaemia (AML), acute lymphocytic leukaemia (ALL), chronic lymphocytic leukaemia (CLL)); also reported in patients free of haematological malignancy

Phenotype stem cell origin

most commonly seen in low grade MDS, usually RA

Epidemiology

frequency: rare; marked male predominance; found mostly in adults; med age: 77

Prognosis

not known

Genes Involved and Proteins

Note
is/are not known

Bibliography

Pubmed IDLast YearTitleAuthors
96899251998Trisomy 15 associated with loss of the Y chromosome in bone marrow: a possible new aging effect.Sinclair EJ et al
86896051996Trisomy 15 in hematological malignancies: six cases and review of the literature.Smith SR et al

Citation

Elizabeth J Sinclair ; Anthony M Potter

+15 or trisomy 15 (as sole autosomal abnormality)

Atlas Genet Cytogenet Oncol Haematol. 1999-05-01

Online version: http://atlasgeneticsoncology.org/haematological/1144/+15-or-trisomy-15-(as-sole-autosomal-abnormality)

External Links