+15 or trisomy 15 (as sole autosomal abnormality)

1999-05-01   Elizabeth J Sinclair , Anthony M Potter 

1.Centre for Human Genetics, Sheffield, United Kingdom

Clinics and Pathology


myeloid and lymphoid lineages (myelodysplastic syndromes (MDS), acute nonlymphocytic leukaemia (AML), acute lymphocytic leukaemia (ALL), chronic lymphocytic leukaemia (CLL)); also reported in patients free of haematological malignancy

Phenotype stem cell origin

most commonly seen in low grade MDS, usually RA


frequency: rare; marked male predominance; found mostly in adults; med age: 77


not known

Genes Involved and Proteins

is/are not known


Pubmed IDLast YearTitleAuthors
96899251998Trisomy 15 associated with loss of the Y chromosome in bone marrow: a possible new aging effect.Sinclair EJ et al
86896051996Trisomy 15 in hematological malignancies: six cases and review of the literature.Smith SR et al


Elizabeth J Sinclair ; Anthony M Potter

+15 or trisomy 15 (as sole autosomal abnormality)

Atlas Genet Cytogenet Oncol Haematol. 1999-05-01

Online version: http://atlasgeneticsoncology.org/haematological/1144/+15-or-trisomy-15-(as-sole-autosomal-abnormality)

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