t(5;16)(q33;q22)

2008-03-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Acute myeloid leukemia (AML)

Epidemiology

Only two cases to date, a 10-month-old male infant with M4-AML, who entered remission, and a 60-year-old male patient with M1-AML who died 4 months after diagnosis. Both patients presented with marked eosinophilia (Bhambhani et al., 1986; Sanada et al., 1989).

Genes Involved and Proteins

Note
Genes involved in this structural anomaly are unknown, although it is likely that CBFb is involved in the disease.

Bibliography

Pubmed IDLast YearTitleAuthors
34558591986Acute myelomonocytic leukemia type M4 with bone marrow eosinophilia and t(5;16)(q33;q22).Bhambhani K et al
27907691989Acute myelogenous leukemia (FAB M1) associated with t(5;16) and eosinophilia. Report of an additional case.Sanada I et al

Citation

Jean-Loup Huret

t(5;16)(q33;q22)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/haematological/1151/t(5;16)(q33;q22)