2007-08-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


Myeloid malignancies

Phenotype stem cell origin

Myloproliferative diseases (MPD) in 3 of 10 available cases (polycytemia vera (PV) in all 3 cases), myelodysplastic syndromes (MDS) in 6 cases (mainly refractory anaemia (RA): 5 cases; RARS in one case), acute myeloid leukaemia (AML) of M7 type in one case.


At least 10 cases; balanced sex ratio (5M/5F); median age was 47 yrs (range 15-81)
Atlas Image
Kaplan-Meier on 10 cases of dic(1;15) from the literature; survivals (in months) were: 4, 14, 23+, 24+, 27, 40+, 93+, 96, 235.


About 60% of cases were still alive 2 to 8 yrs after diagnosis (see figure1), but with a too short follow up of a too small cohort, no real conclusions can be drawn. It is likely that the prognosis depend more on the haematological diagnosis (AML versus MDS, vs MPD).

Genes Involved and Proteins

Genes involved are unknown; the translocation breakpoints are likely to be in heterochromatic regions


Pubmed IDLast YearTitleAuthors
120913562002Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Français de Cytogénétique Hématologique (GFCH).Dastugue N et al
23404871990Cytogenetic analysis of 54 cases of myelodysplastic syndrome.Jotterand-Bellomo M et al
27138191989A dysmorphic child with myelodysplasia characterized by a duplication of 1q and multiple duplications of 3q.Mascarello JT et al
39549641986An identical translocation between chromosome 1 and 15 in two patients with myelodysplastic syndromes.Mecucci C et al
86309881996Dicentric (1;15) in myeloid disorders.Michaux L et al
37062911986Trisomy 1q in polycythemia vera and its relation to disease transition.Swolin B et al
12512211976Cytogenetic studies in polycythemia vera.Wurster-Hill D et al


Atlas Image
dic(1;15)(p11;p11) G- banding - Courtesy Catherine Roche-Lestienne, Olivier Theisen, Jean-Luc Lai.


Jean-Loup Huret


Atlas Genet Cytogenet Oncol Haematol. 2007-08-01

Online version: http://atlasgeneticsoncology.org/haematological/1159/dic(1;15)(p11;p11)