t(18;21)(q21;q22) RUNX1/?

2000-02-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

acute myeloid leukemia (AML) secondary to toxic exposure

Note

only one case, but with features identical to 2 other cases: one case of t(1;21)(p36;q22), and one case of t(19;21)(q13.4;q22)

Phenotype stem cell origin

M2-AML

Etiology

about 50 years after radiation exposure from nuclear explosion

Clinics

pancytopenia preceeded leukemia

Evolution

complete remission was obtained and the patient returned to the previous pancytopenia; subsequent relapse occurred

Genes Involved and Proteins

Note
the gene involved in 18q21 is unknown
Gene name
RUNX1 (runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene))
Location
21q22.12
Dna rna description
transcription is from telomere to centromere
Protein description
contains a Runt domain and, in the C-term, a transactivation domain; forms heterodimers; widely expressed; nuclear localisation; transcription factor (activator) for various hematopoietic-specific genes

Bibliography

No bibliography items were found for this article.

Citation

Jean-Loup Huret

t(18;21)(q21;q22) RUNX1/?

Atlas Genet Cytogenet Oncol Haematol. 2000-02-01

Online version: http://atlasgeneticsoncology.org/haematological/1187/t(18;21)(q21;q22)

External Links