t(9;11)(q34;q23) FNBP1/KMT2A

2001-06-01   Arndt Borkhardt , Uta Fuchs 

1.Children s University Hospital Giessen, Hematology &Oncology, Feulgenstr. 12, 35392 Giessen, Germany
2.Childrens University Hospital Giessen, Hematology &Oncology, Feulgenstr. 12, 35392 Giessen, Germany

Clinics and Pathology

Disease

acute myeloid leukemia (AML)

Phenotype stem cell origin

one case of M4-AML

Epidemiology

unknown

Clinics

WBC 35 X 109/l

Prognosis

poor

Result of the Chromosomal Anomaly

Description

5-MLL/FBP17-3
Atlas Image

Description

Hybrid transcript MLL/FBP17 contains the following domains: from MLL: AT-hook, DNA-Methyltransferase, Zinc-Fingers; from FBP17:cdc15 homology region, putative rho-binding domain, SH3-domain

Expression localisation

nuclear

Oncogenesis

unknown

Bibliography

Pubmed IDLast YearTitleAuthors
114386822001The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia.Fuchs U et al

Citation

Arndt Borkhardt ; Uta Fuchs

t(9;11)(q34;q23) FNBP1/KMT2A

Atlas Genet Cytogenet Oncol Haematol. 2001-06-01

Online version: http://atlasgeneticsoncology.org/haematological/1205/t(9;11)(q34;q23)

External Links