t(4;5)(q31;q31)

2008-02-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML)

Phenotype stem cell origin

The AML case was a M6

Epidemiology

Only three cases available; patients (one male, two female patients) were aged 68, 70, and 80 (yrs).

Cytogenetics

Cytogenetics morphological

The 3 cases were found using multi-FISH techniques; this translocation may therefore be partially cryptic, especially so as it is found in complex karyotypes.

Additional anomalies

Major karyotypic anomalies were present in 3 out of 3 cases; +X and +8 were found in one case.

Genes Involved and Proteins

Note
Genes involved are unknown.

Bibliography

Pubmed IDLast YearTitleAuthors

Citation

Jean-Loup Huret

t(4;5)(q31;q31)

Atlas Genet Cytogenet Oncol Haematol. 2008-02-01

Online version: http://atlasgeneticsoncology.org/haematological/1206/favicon/favicon-32x32.png