2008-02-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


Myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML)

Phenotype stem cell origin

The AML case was a M6


Only three cases available; patients (one male, two female patients) were aged 68, 70, and 80 (yrs).


Cytogenetics morphological

The 3 cases were found using multi-FISH techniques; this translocation may therefore be partially cryptic, especially so as it is found in complex karyotypes.

Additional anomalies

Major karyotypic anomalies were present in 3 out of 3 cases; +X and +8 were found in one case.

Genes Involved and Proteins

Genes involved are unknown.


Pubmed IDLast YearTitleAuthors
117469882002Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH.Van Limbergen H et al
90903891997Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping.Veldman T et al


Jean-Loup Huret


Atlas Genet Cytogenet Oncol Haematol. 2008-02-01

Online version: http://atlasgeneticsoncology.org/haematological/1206/t(4;5)(q31;q31)

External Links