2008-02-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


Acute myeloid leukaemia (AML); non-Hodgkin lymphoma (NHL)


The disease is likely to be heterogeneous, with different phenotypes (AML and NHL) for a given breakpoint (1p31 and 8q22), and possibly similar or different breakpoints in different AML cases.


3 cases of AML: two of which were M2 cases (ages and sex were: 84 years/F; 40 years/ M; ?/?); the NHL case was 71 year-old male patient with a small cleaved cell follicular lymphoma

Genes Involved and Proteins

Genes involved are unknown.


Pubmed IDLast YearTitleAuthors
68506081983Nonrandom chromosome abnormalities in lymphoma.Bloomfield CD et al
89081651996Complex chromosome translocations of standard t(8;21) and t(15;17) arise from a two-step mechanism as evidenced by fluorescence in situ hybridization analysis.Calabrese G et al
111653152001Acute leukemia cytogenetics: an evaluation of combining G-band karyotyping with multi-color spectral karyotyping.Kerndrup GB et al
23539671990Acute megakaryocytic leukemia.Moertel CL et al
117469882002Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH.Van Limbergen H et al


Jean-Loup Huret


Atlas Genet Cytogenet Oncol Haematol. 2008-02-01

Online version: http://atlasgeneticsoncology.org/haematological/1207/t(1;8)(p22-p32;q22-q23)