t(9;21)(p22;q22)

2007-12-01 Jean-Loup Huret Affiliation

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Treatment related acute myeloid leukaemia (t-AML)

Phenotype stem cell origin

Only 2 cases to date, a M4-AML and a case with no data

Clinics

A 7 year old boy presented with M4-AML 67 months after treatment of a T-ALL with epipodophyllotoxins

Prognosis

No data

Note

It is likely that RUNX1 was involved in the translocation. RUNX1, also called AML1 or CBFA2, is a transcription factor, critical regulator of hematopoietic-cell development, involved in many de novo and treatment related leukaemias.

Article Bibliography

Pubmed ID	Last Year	Title	Authors
1944468	1991	Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia.	Pui CH et al
11921272	2002	21q22 balanced chromosome aberrations in therapy-related hematopoietic disorders: report from an international workshop.	Slovak ML et al

Citation

Jean-Loup Huret

t(9;21)(p22;q22)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/haematological/1304/t(9;21)(p22;q22)