t(1;2)(q12;q37) in acute leukemias

2014-11-01   Shen Yueyang  , Shen Yueyang  , Shen Yueyang  

1.Cytogenetics Laboratory, Department of Pathology, Laboratory Medicine, Vancouver, BC, Canada. helene.bruyere@vch.ca
2.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France


Review on t(1;2)(q12;q37), with data on clinics.

Clinics and Pathology


Acute leukemias

Phenotype stem cell origin

1 case of M0 acute myeloid leukemia (AML), 1 case of M4 AML, 1 case of M5 AML with monocytic/monoblastic differentiation and 1 case of L1 acute lymphoblastic leukemia (ALL).


a 76 yr old female patient, a 81 yr old male patient, a 31 yr old male patient and a 69 yr old male patient (ALL). A t(1;2)(q12;q37 has also been found in myelodysplastic syndrome (RAEB), 2 multiple myeloma cases, and 2 hepatoblastoma cases.




Pubmed IDLast YearTitleAuthors
106024181999Fluorescence in situ hybridization analysis of chromosome 1 abnormalities in hematopoietic disorders: rearrangements of DNA satellite II and new recurrent translocations.Busson-Le Coniat M et al
37081601986Prognostic implications of morphology and karyotype in primary myelodysplastic syndromes.Jacobs RH et al
115680112001Hypodiploidy is a major prognostic factor in multiple myeloma.Smadja NV et al



Only a few cases reported to date, poorly known
Atlas Image
G-band analysis - partial karyotype showing der(2)t(1;2)(q12;q37) Courtesy Drs. Tanya Gillan and Hŕ Bruyè, Vancouver General Hospital Cytogenetics Laboratory


Shen Yueyang ; Shen Yueyang ; Shen Yueyang

t(1;2)(q12;q37) in acute leukemias

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/haematological/1317/t(1;2)(q12;q37)-in-acute-leukemias

Historical Card

2000-02-01 t(1;2)(q12;q37) in acute leukemias by  Jean-Loup Huret 

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

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