1.Cytogenetics Laboratory, Pathology Department, Detroit Medical Center, Wayne, State University School of Medicine, Detroit, MI USA; firstname.lastname@example.org
; Chronic eosinophilic leukemia (CEL) not otherwise specified (NOS) and idiopathic hypereosinophilic syndrome (HES) are rare hematologic disorders characterized by chronic, unexplained eosinophilia with manifestation of organ involvement related to eosinophil infiltration, in the absence of evidence of secondary causes such as parasitic infestation, allergy, or neoplasm. Neither CEL-NOS nor idiopathic HES show Ph chromosome/ BCR-ABL fusion gene or other genetically defined entities such as PDGFRA, PDGFRB, or FGFR1 abnormalities.
Anwar N. Mohamed
Chronic Eosinophilic Leukemia-Not Otherwise Specified (CEL-NOS)Idiopathic Hypereosinophilic Syndrome (IHES)
Atlas Genet Cytogenet Oncol Haematol. 2018-06-01
Online version: http://atlasgeneticsoncology.org/haematological/1340/chreosinoleukid1340