t(1;6)(p35;p25) ?/IRF4

2005-01-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


Chronic lymphocytic leukemia (CLL)

Phenotype stem cell origin

Unmutated status of IgVH (an unfavourable prognostic feature) was found in all cases.


8 patients to date, representing 0.5% of CLL cases in a country based survey; sex ratio: 6 male/2 female patients, aged 33-81 years (med: 62.5 years).


Two cases in Binet stage A, 4 in stage B, 2 in stage C. Normal LDH values in 7 of 8.


Yet unknown (median follow up is only 28 months), but 3 patients developed a diffuse large B-cell lymphoma (DLBCL), and 3 patients (2 of which with DLBCL) died at 29, 76, and 95 months.

Genes Involved and Proteins

IRF4 (6p25.2) is possibly involved in the translocation. The gene in 1p35.3 is unknown.

Highly cited references

Pubmed IDYearTitleCitations
335966422022The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma.4
355002272022Racial and ethnic differences in clonal hematopoiesis, tumor markers, and outcomes of patients with multiple myeloma.2
345606832022A Comprehensive Clinicopathologic and Molecular Study of 19 Primary Effusion Lymphomas in HIV-infected Patients.2
359151692022Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.1
341177202022The Immunity-malignancy equilibrium in multiple myeloma: lessons from oncogenic events in plasma cells.1
341294152022Platycodin D attenuates airway inflammation via suppression Th2 transcription factor in a murine model of acute asthma.1
343316642022IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essential thrombocythemia.1
353831252022Anisodamine Enhances Macrophage M2 Polarization through Suppressing G9a-Mediated Interferon Regulatory Factor 4 Silencing to Alleviate Lipopolysaccharide-Induced Acute Lung Injury.1
354599092022IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity.1
354491872022Genome-wide association study of actinic keratosis identifies new susceptibility loci implicated in pigmentation and immune regulation pathways.1
351819512022Investigation of Molecular Iridium Fluorides IrFn (n=1-6): A Combined Matrix-Isolation and Quantum-Chemical Study.1
349135322022The molecular basis for the development of adult T-cell leukemia/lymphoma in patients with an IRF4K59R mutation.1
347754952022microRNA-155-5p initiates childhood acute lymphoblastic leukemia by regulating the IRF4/CDK6/CBL axis.1
346977232022Intestinal Protein Characterisation of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in Inflammatory Bowel Disease (IBD) and Fatal COVID-19 Infection.1
354334612022Integrated Multi-Omics Analysis Identified PTPRG and CHL1 as Key Regulators of Immunophenotypes in Clear Cell Renal Cell Carcinoma(ccRCC).1
352285232022Targeting macrophage TFEB-14-3-3 epsilon Interface by naringenin inhibits abdominal aortic aneurysm.1
349293422022IRF4 transcriptionally activate HOTAIRM1, which in turn regulates IRF4 expression, thereby affecting Th9 cell differentiation and involved in allergic rhinitis.1
355825272022Drug resistance and minimal residual disease in multiple myeloma.1
350257632022Macrophage interferon regulatory factor 4 deletion ameliorates aristolochic acid nephropathy via reduced migration and increased apoptosis.1
360333972022BACH2 in TRegs Limits the Number of Adipose Tissue Regulatory T Cells and Restrains Type 2 Immunity to Fungal Allergens.0
360316342022Artesunate suppresses Th17 response via inhibiting IRF4-mediated glycolysis and ameliorates Sjog̈ren's syndrome.0
360163352022Expression of NAC1 Restrains the Memory Formation of CD8+ T Cells during Viral Infection.0
360123912022RNA-Seq Analysis of UPM-Exposed Epithelium Co-Cultivated with Macrophages and Dendritic Cells in Obstructive Lung Diseases.0
359934512022Postbiotics engage IRF4 in adipocytes to promote sex-dependent changes in blood glucose during obesity.0
359930412022A Comprehensive Analysis of Interferon Regulatory Factor Expression: Correlation with Immune Cell Infiltration and Patient Prognosis in Endometrial Carcinoma.0
359844882022Primary effusion anaplastic large cell lymphoma with indolent clinical course and IRF4/DUSP22 rearrangement: a case report expanding the spectrum of effusion-based lymphoma.0
358308592022IRF8 deficiency induces the transcriptional, functional, and epigenetic reprogramming of cDC1 into the cDC2 lineage.0
360095862022Genomic Aberrations Generate Fusion Gene FOXK2::TP63 and Activate NFKB1 in Cutaneous T-Cell Lymphoma.0
359830772022Immunogenomic-Based Analysis of Hierarchical Clustering of Diffuse Large Cell Lymphoma.0
359636212022Regulation of microglial activation in stroke in aged mice: a translational study.0
359620592022Single-cell ATAC-seq maps the comprehensive and dynamic chromatin accessibility landscape of CAR-T cell dysfunction.0
358963362022Peripheral CD23hi/IgE+ Plasmablasts Secrete IgE and Correlate with Allergic Disease Severity.0
358098832022Redclaw crayfish (Cherax quadricarinatus) responds to Vibrio parahaemolyticus infection by activating toll and immune deficiency signaling pathways and transcription of associated immune response genes.0
355444672022Correlation of the transcription factors IRF4 and BACH2 with the abnormal NFATC1 expression in T cells from chronic myeloid leukemia patients.0
355444132022Dissecting the impact of bromodomain inhibitors on the Interferon Regulatory Factor 4-MYC oncogenic axis in multiple myeloma.0
351343162022Bioinformatics analysis deciphering the transcriptomic signatures associated with signalling pathways and prognosis in the myelodysplastic syndromes.0
358844962022Classifying Germinal Center Derived Lymphomas-Navigate a Complex Transcriptional Landscape.0
358771992022MUM1/IRF4 is Highly Expressed in Dermatopathic Lymphadenopathy: Potential Utility in Diagnosis and Differential Diagnosis.0
358746752022Comprehensive Analyses of Immune Subtypes of Stomach Adenocarcinoma for mRNA Vaccination.0
357807742022Interferon regulatory factor 4 (IRF4) promotes lipopolysaccharide-induced colonic mucosal epithelial cell proliferation by regulating macrophage polarization.0
349529452022Genomic landscape of Epstein-Barr virus-positive extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue.0
359288722022Cell-Free DNA Sequencing of Intraocular Fluid as Liquid Biopsy in the Diagnosis of Vitreoretinal Lymphoma.0
359086292022Lineage- and Stage-Specific Oncogenicity of IRF4.0
359081802022Trappc1 deficiency impairs thymic epithelial cell development by breaking endoplasmic reticulum homeostasis.0
358849132022Downregulation of STAT3 in Epstein-Barr Virus-Positive Hodgkin Lymphoma.0
358835112022Kinetic Changes in B7 Costimulatory Molecules and IRF4 Expression in Human Dendritic Cells during LPS Exposure.0
358832132022Detection and Characterization of Paraproteinemia in Canine Chronic B-cell Lymphocytic Leukemia Using Routine and Free Light Chain Immunofixation.0
359685902022[Large B-cell lymphoma with IRF4 rearrangement: six case reports and a literature review].0
357678862022Essential Transcription Factors and Functional Roles of Follicular Helper T Cells ‎in Human Autoimmune Diseases.0
357659792022The hMeDIP-Seq identified INPP4A as a novel biomarker for eosinophilic chronic rhinosinusitis with nasal polyps.0
357597282022Aberrant expansion of spontaneous splenic germinal centers induced by hallmark genetic lesions of aggressive lymphoma.0
357552862022A BRD4 PROTAC nanodrug for glioma therapy via the intervention of tumor cells proliferation, apoptosis and M2 macrophages polarization.0
356908632022Dihydromyricetin ameliorates diet-induced obesity and promotes browning of white adipose tissue by upregulating IRF4/PGC-1α.0
356755222022ETS1 is a novel transcriptional regulator of adult T-cell leukemia/lymphoma of North American descent.0
354119502022USP7 sustains an active epigenetic program via stabilizing MLL2 and WDR5 in diffuse large B-cell lymphoma.0
353904442022Variants in proinflammatory genes IL1RL1, IL1B and IRF4 are associated with overweight in a pediatric Brazilian population.0
352554292022De Novo CD5-positive diffuse large B-cell lymphoma: A genomic profiling study and prognostic analysis of 46 patients.0
358374082022JunB Is Critical for Survival of T Helper Cells.0
358369282022Nematode microRNAs can Individually Regulate Interferon Regulatory Factor 4 and mTOR in Differentiating T Helper 2 Lymphocytes and Modulate Cytokine Production in Macrophages.0
357139592022Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome.0
356978262022Construction and analysis of a ceRNA network and patterns of immune infiltration in chronic rhinosinusitis with nasal polyps: based on data mining and experimental verification.0
350014252022Primary cutaneous CD8+ cytotoxic T-cell lymphoma of the face with intraoral involvement, resulting in facial nerve palsy after chemotherapy.0
356644362022Interferon Regulatory Factor Family Genes: At the Crossroads between Immunity and Head and Neck Squamous Carcinoma.0
356466662022Single-Cell Proteomics and Tumor RNAseq Identify Novel Pathways Associated With Clofazimine Sensitivity in PI- and IMiD- Resistant Myeloma, and Putative Stem-Like Cells.0
355924932022Retraction Notice to: H3K27 demethylase KDM6B aggravates ischemic brain injury through demethylation of IRF4 and Notch2-dependent SOX9 activation.0
355049242022IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma.0
350651382022Modulation of fish immune response by interferon regulatory factor 4 in redlip mullet (Liza haematocheilus): Delineation through expression profiling, antiviral assay, and macrophage polarization analysis.0
355687712022Novel immune subtypes identification of HER2-positive breast cancer based on immunogenomic landscape.0
355600372022Primary cutaneous anaplastic large cell lymphoma with DUSP22-IRF4 rearrangement demonstrating a biphasic histopathologic pattern and a complete natural regression.0
355536282022Expression levels of cellular inhibitor of apoptosis proteins and colitogenic cytokines are inversely correlated with the activation of interferon regulatory factor 4.0
355081352022Topologically associating domains are disrupted by evolutionary genome rearrangements forming species-specific enhancer connections in mice and humans.0
355072912022Plasmablast-like Phenotype Among Antigen-Experienced CXCR5-CD19low B Cells in Systemic Lupus Erythematosus.0
350306322022Distinct clinical and genetic features of hepatitis B virus-associated follicular lymphoma in Chinese patients.0
355183502022Aloe-Emodin Ameliorates Diabetic Nephropathy by Targeting Interferon Regulatory Factor 4.0
354720722022Reduced IRF4 expression promotes lytic phenotype in Type 2 EBV-infected B cells.0
354644682022Co-Expression of the B-Cell Key Transcription Factors Blimp-1 and IRF4 Identifies Plasma Cells in the Pig.0
353973662022IRF4 suppresses osteogenic differentiation of BM-MSCs by transcriptionally activating miR-636/DOCK9 axis.0
353959882022[Bioinformatics Analysis of Microarray Data in Myelodysplastic Syndrome Based on Gene Expression Omnibus Database].0
353886532022Genome-wide expression reveals potential biomarkers in breast cancer bone metastasis.0
352351072022Lipoxin A4 regulates M1/M2 macrophage polarization via FPR2-IRF pathway.0
352199102022CCR1 antagonist ameliorates experimental autoimmune encephalomyelitis by inhibition of Th9/Th22-related markers in the brain and periphery.0
350225002022Differential roles of BAF and PBAF subunits, Arid1b and Arid2, in MLL-AF9 leukemogenesis.0
346540552022Diffuse large B-cell lymphomas in adults with aberrant coexpression of CD10, BCL6, and MUM1 are enriched in IRF4 rearrangements.0
355022442022Dexmedetomidine Activates Akt, STAT6 and IRF4 Modulating Cytoprotection and Macrophage Anti-Inflammatory Phenotype Against Acute Lung Injury in vivo and in vitro.0
354431732022Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization.0
344182352022Biophysical evidence to support and extend the vitamin D-folate hypothesis as a paradigm for the evolution of human skin pigmentation.0
353570052022Flt3L, LIF, and IL-10 combination promotes the selective in vitro development of ESAMlow cDC2B from murine bone marrow.0
353006942022Molecular identification and functional characterization of IRF4 from common carp (Cyprinus carpio. L) in immune response: a negative regulator in the IFN and NF-κB signalling pathways.0
352256482022Circ_0020123 regulates autophagy, glycolysis, and malignancy by upregulating IRF4 through eliminating miR-193a-3p-mediated suppression of IRF4 in non-small cell lung cancer.0
347052952022Primary cutaneous anaplastic large-cell lymphoma with aberrant cytokeratin expression: An unusual mimicker of poorly differentiated carcinomas.0
343103682022Reactive Intralymphovascular Immunoblastic Proliferations Mimicking Aggressive Lymphomas.0
353612602022RNA sequencing identifies novel regulated IRE1-dependent decay targets that affect multiple myeloma survival and proliferation.0
353507152022Deciphering Key Foreign Body Reaction-Related Transcription Factors and Genes Through Transcriptome Analysis.0
353383472022SUMOylation inhibition enhances multiple myeloma sensitivity to lenalidomide.0
351838242022Immunohistochemical algorithms and gene expression profiling in primary cutaneous B-cell lymphoma.0
350197212022Host T Cell Dedifferentiation Effects Drive HIV-1 Latency Stability.0
349627002022Importance of clinical correlation in the diagnosis of pediatric B-cell lymphomas.0
348079932022The Ccl17 gene encoding TARC is synergistically transactivated by PU.1 and IRF4 driven by the mammalian common promoter in dendritic cells.0
346991052022Patch/plaque mycosis-fungoides-like presentations of DUSP22-translocated T-cell lymphomas.0
351421512022A pilot study of the use of dynamic cfDNA from aqueous humor and vitreous fluid for the diagnosis and treatment monitoring of vitreoretinal lymphomas.0


Pubmed IDLast YearTitleAuthors
155102102005Translocation t(1;6)(p35.3;p25.2): a new recurrent aberration in "unmutated" B-CLL.Michaux L et al


Atlas Image
t(1;6)(p35;p25) G- banding - top: Courtesy Melanie Zenger and Claudia Haferlach; bottom Courtesy Aurelia Meloni-Ehrig.


Jean-Loup Huret

t(1;6)(p35;p25) ?/IRF4

Atlas Genet Cytogenet Oncol Haematol. 2005-01-01

Online version: http://atlasgeneticsoncology.org/haematological/1378/t(1;6)(p35;p25)

External Links