t(1;6)(p35;p25) ?/IRF4

2005-01-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Chronic lymphocytic leukemia (CLL)

Phenotype stem cell origin

Unmutated status of IgVH (an unfavourable prognostic feature) was found in all cases.

Epidemiology

8 patients to date, representing 0.5% of CLL cases in a country based survey; sex ratio: 6 male/2 female patients, aged 33-81 years (med: 62.5 years).

Clinics

Two cases in Binet stage A, 4 in stage B, 2 in stage C. Normal LDH values in 7 of 8.

Prognosis

Yet unknown (median follow up is only 28 months), but 3 patients developed a diffuse large B-cell lymphoma (DLBCL), and 3 patients (2 of which with DLBCL) died at 29, 76, and 95 months.

Genes Involved and Proteins

Note
IRF4 (6p25.2) is possibly involved in the translocation. The gene in 1p35.3 is unknown.

Bibliography

Pubmed IDLast YearTitleAuthors
155102102005Translocation t(1;6)(p35.3;p25.2): a new recurrent aberration in "unmutated" B-CLL.Michaux L et al

Summary

Atlas Image
t(1;6)(p35;p25) G- banding - top: Courtesy Melanie Zenger and Claudia Haferlach; bottom Courtesy Aurelia Meloni-Ehrig.

Citation

Jean-Loup Huret

t(1;6)(p35;p25) ?/IRF4

Atlas Genet Cytogenet Oncol Haematol. 2005-01-01

Online version: http://atlasgeneticsoncology.org/haematological/1378/t(1;6)(p35;p25)

External Links