t(1;6)(p35;p25) ?/IRF4

2005-01-01   Jean-Loup Huret  

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Chronic lymphocytic leukemia (CLL)

Phenotype stem cell origin

Unmutated status of IgVH (an unfavourable prognostic feature) was found in all cases.

Epidemiology

8 patients to date, representing 0.5% of CLL cases in a country based survey; sex ratio: 6 male/2 female patients, aged 33-81 years (med: 62.5 years).

Clinics

Two cases in Binet stage A, 4 in stage B, 2 in stage C. Normal LDH values in 7 of 8.

Prognosis

Yet unknown (median follow up is only 28 months), but 3 patients developed a diffuse large B-cell lymphoma (DLBCL), and 3 patients (2 of which with DLBCL) died at 29, 76, and 95 months.

Genes Involved and Proteins

Note
IRF4 (6p25.2) is possibly involved in the translocation. The gene in 1p35.3 is unknown.

Highly cited references

Pubmed IDYearTitleCitations
201929942010IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?173
368149122023Regulatory effects of IRF4 on immune cells in the tumor microenvironment.132
379356542023Transcriptional reprogramming by mutated IRF4 in lymphoma.116
394734892017Role of IRF4-Mediated Inflammation: Implication in Neurodegenerative Diseases.114
377553312023Roles of interferon regulatory factor 4 in the AKI-CKD transition, glomerular diseases and kidney allograft rejection.107
360778492022IRF4 as an Oncogenic Master Transcription Factor.106
354720722022Reduced IRF4 expression promotes lytic phenotype in Type 2 EBV-infected B cells.96
393560342024Targeting Immunoproteasome in Polarized Macrophages Ameliorates Experimental Emphysema Via Activating NRF1/2-P62 Axis and Suppressing IRF4 Transcription.95
376970972023Control of nutrient uptake by IRF4 orchestrates innate immune memory.93
388806592024Interferon regulatory factor 4 modulates epigenetic silencing and cancer-critical pathways in melanoma cells.93
355049242022IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma.92
193838292009IRF4: Immunity. Malignancy! Therapy?87
334064052021Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma.85
377677682024Transcriptional Heterogeneity Overcomes Super-Enhancer Disrupting Drug Combinations in Multiple Myeloma.84
295373672018IRF4 haploinsufficiency in a family with Whipple's disease.82
342823302021BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells.80
343107762021Impact of hypoxia on the pathogenesis and therapy resistance in multiple myeloma.80
389061562024IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma.78
319491432020Genomic programming of IRF4-expressing human Langerhans cells.78
374325942024Central IRF4/5 Signaling Are Critical for Microglial Activation and Impact on Stroke Outcomes.78
366628842023A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency.77
334765752021Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption.77
378090682023Human inborn errors of immunity associated with IRF4.75
364953692023The dynamic functions of IRF4 in B cell malignancies.75
384579262024C-terminal binding protein 2 is a novel tumor suppressor targeting the MYC-IRF4 axis in multiple myeloma.75
361827452022Druggable host gene dependencies in primary effusion lymphoma.74
321252912020IRF4 instructs effector Treg differentiation and immune suppression in human cancer.73
386052252024Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions.72
327954022020High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity.72
330427612020IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway.67
359636212022Regulation of microglial activation in stroke in aged mice: a translational study.66
267281872016The KDM3A-KLF2-IRF4 axis maintains myeloma cell survival.65
350590382021Molecular interactions of IRF4 in B cell development and malignancies.63
390037762024A dual-gene panel of two fragments of methylated IRF4 and one of ZEB2 in plasma cell-free DNA for gastric cancer detection.62
377704802023Metabolic crosstalk between skeletal muscle cells and liver through IRF4-FSTL1 in nonalcoholic steatohepatitis.60
300785532018Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin.60
384914842024IRF4-mediated Treg phenotype switching can aggravate hyperoxia-induced alveolar epithelial cell injury.58
347590172021B Cell-Intrinsic IRF4 Haploinsufficiency Impairs Affinity Maturation.58
361944942022IRF4 expression by lung dendritic cells drives acute but not Trm cell-dependent memory Th2 responses.58
249959792014IRF4 is a key thermogenic transcriptional partner of PGC-1α.57
374695132023IRF4 is required for migration of CD4(+) T cells to the intestine but not for Th2 and Th17 cell maintenance.54
369170082023A neomorphic mutation in the interferon activation domain of IRF4 causes a dominant primary immunodeficiency.51
187756692008Interferon regulatory factor 4 and 8 in B-cell development.51
317388232020Distinct molecular profile of IRF4-rearranged large B-cell lymphoma.50
292217302017Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4(+) T Cell Dysfunction.50
361598332022Jmjd3/IRF4 axis aggravates myeloid fibroblast activation and m2 macrophage to myofibroblast transition in renal fibrosis.50
305865992019Myeloid cell IRF4 signaling protects neonatal brains from hypoxic ischemic encephalopathy.49
395013022024METTL3 facilitates kidney injury through promoting IRF4-mediated plasma cell infiltration via an m6A-dependent manner in systemic lupus erythematosus.47
239263032013A role for IRF4 in the development of CLL.47
361291972023Novel antimyeloma therapeutic option with inhibition of the HDAC1-IRF4 axis and PIM kinase.47
335339132021Structural determinants of the IRF4/DNA homodimeric complex.46
372879822023IRF4 downregulation improves sensitivity and endurance of CAR T cell functional capacities.46
381954652024IRF4 affects the protective effect of regulatory T cells on the pulmonary vasculature of a bronchopulmonary dysplasia mouse model by regulating FOXP3.45
347285382021SOX10 Regulates Melanoma Immunogenicity through an IRF4-IRF1 Axis.43
381789022023Continuous Expression of Interferon Regulatory Factor 4 Sustains CD8(+) T Cell Immunity against Tumor.40
378606972023The transcription factor IRF4 determines the anti-tumor immunity of CD8(+) T cells.39
353383472023SUMOylation inhibition enhances multiple myeloma sensitivity to lenalidomide.39
245101252014IRF4 is a novel mediator for neuronal survival in ischaemic stroke.39
220032002011MicroRNA-125b potentiates macrophage activation.38
357139592022Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome.35
349135322022The molecular basis for the development of adult T-cell leukemia/lymphoma in patients with an IRF4(K59R) mutation.31
370817862023IRF4 rearrangement may predict favorable prognosis in children and young adults with primary head and neck large B-cell lymphoma.30
342534542021IRF4 ablation in B cells abrogates allogeneic B cell responses and prevents chronic transplant rejection.30
185680252008IRF4 addiction in multiple myeloma.29
353973662022IRF4 suppresses osteogenic differentiation of BM-MSCs by transcriptionally activating miR-636/DOCK9 axis.29
391231882024Suppression of SENP3 enhances macrophage alternative activation by mediating IRF4 de-SUMOylation in ESCC progression.28
348231762022Identification and antiviral effect of Cherry Valley duck IRF4.28
359934512022Postbiotics engage IRF4 in adipocytes to promote sex-dependent changes in blood glucose during obesity.24
368107962023Prevalence of IRF4 rearrangement in large B-cell lymphomas of the Waldeyer's ring in adults.24
217914292011IRF4 mutations in chronic lymphocytic leukemia.15
372115582023Repression of interferon regulatory factor-4 (IRF4) hyperactivation restricts murine lupus.4
292464432017Transcription Factor IRF4 Promotes CD8(+) T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection.0
201823472010MUM1/IRF4: A Review.0
359086292022Lineage- and Stage-Specific Oncogenicity of IRF4.0
386153792024Roles of IRF4 in various immune cells in systemic lupus erythematosus.0
389698722024Epigenetic recording of stimulation history reveals BLIMP1-BACH2 balance in determining memory B cell fate upon recall challenge.0
300985182018IRF4 in multiple myeloma-Biology, disease and therapeutic target.0
389436412024IRF4 impedes human CD8 T cell function and promotes cell proliferation and PD-1 expression.0
230106322012Targeting IRF4 in autoimmune diseases.0
225008332012The diverse roles of IRF4 in late germinal center B-cell differentiation.0
360811782022Regulatory network of BLIMP1, IRF4, and XBP1 triad in plasmacytic differentiation and multiple myeloma pathogenesis.0
247821592014IRF4 at the crossroads of effector T-cell fate decision.0
381647492024IRF4 induces M1 macrophage polarization and aggravates ulcerative colitis progression by the Bcl6-dependent STAT3 pathway.0
278267522016Essential role of interferon regulatory factor 4 (IRF4) in immune cell development.0
391721062024Clinicopathological and Molecular Characteristics of Rare EBV-associated Diffuse Large B-cell Lymphoma With IRF4 Rearrangement.0
369445792023Lymphomatoid papulosis with DUSP22-IRF4 rearrangement: A case report and literature review.0
373851242023Inhibition of IL-4/STAT6/IRF4 signaling reduces the epithelial-mesenchymal transition in eosinophilic chronic rhinosinusitis with nasal polyps.0
394374872024IRF4: A potential prognostic biomarker for immunotherapy in NSCLC.0
362650152022The Double Face of IRF4 in Metabolic Reprogramming.0
376346512023Follicular lymphoma and diffuse large B-cell lymphoma with BCL2 and IRF4 rearrangements in adult patients.0
281036332017IRF4 rs12203592 functional variant and melanoma survival.0
341177202022The Immunity-malignancy equilibrium in multiple myeloma: lessons from oncogenic events in plasma cells.0
302185812019A hyperactive mutant of interferon-regulatory factor 4.0
336231392021IRF4 modulates the response to BCR activation in chronic lymphocytic leukemia regulating IKAROS and SYK.0
118469832002The role of IRF-4 in transcriptional regulation.0
319720022020Feed-forward regulatory loop driven by IRF4 and NF-κB in adult T-cell leukemia/lymphoma.0
379626842024Large B-cell lymphoma with IRF4 rearrangement: a multi-centric study with focus on potential misleading phenotypes.0
309077232019IRF4 promotes Epstein-Barr virus activation in Burkitt's lymphoma cells.0
276016242016Interferon regulatory factor 4 (IRF4) controls myeloid-derived suppressor cell (MDSC) differentiation and function.0
346701172022RNF2 promotes the progression of colon cancer by regulating ubiquitination and degradation of IRF4.0

Article Bibliography

Pubmed IDLast YearTitleAuthors
155102102005Translocation t(1;6)(p35.3;p25.2): a new recurrent aberration in "unmutated" B-CLL.Michaux L et al

Summary

Atlas Image
t(1;6)(p35;p25) G- banding - top: Courtesy Melanie Zenger and Claudia Haferlach; bottom Courtesy Aurelia Meloni-Ehrig.

Citation

Jean-Loup Huret

t(1;6)(p35;p25) ?/IRF4

Atlas Genet Cytogenet Oncol Haematol. 2005-01-01

Online version: http://atlasgeneticsoncology.org/haematological/1378/t(1;6)(p35;p25)-irf4