t(3;14)(p14;q32) IGH/FOXP1

2005-07-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Extra-nodal Marginal Zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (MALT) type, also called MALT lymphoma

Note

MALT lymphomas without the t(3;14) are frequently associated with either a t(1;14)(p22;q32) ( BCL10 / IGH), a t(11;18)(q21;q21) ( API2 / MALT1, or a t(14;18)(q32;q21) (IGH/MALT1)

Epidemiology

9 cases detected to date

Clinics

MALT lymphoma is an indolent disease involving most often the stomach, the lung, the thyroid, the salivary gland, the orbit, and the skin, with a non random anatomic distribution according to the translocation. The t(3;14) is frequently found in MALT lymphomas of the thyroid, the orbit, and the skin.

Genes Involved and Proteins

Gene name
FOXP1 (Forkhead box P1)
Location
3p13
Protein description
Transcription factor; member of the FOXP subfamily, characterized by a DNA binding forkhead.
Gene name
IGH (Immunoglobulin Heavy)
Location
14q32.33

Result of the Chromosomal Anomaly

Description

Breakpoint upstream the first 5 non coding exon of FOXP1

Highly cited references

Pubmed IDYearTitleCitations
244164502014Non-IG aberrations of FOXP1 in B-cell malignancies lead to an aberrant expression of N-truncated isoforms of FOXP1.9
180401432007MALT lymphoma : recent advances in aetiology and molecular genetics.25
171225102006The incidence and anatomic site specificity of chromosomal translocations in primary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in North America.43

Bibliography

Pubmed IDLast YearTitleAuthors
157037842005T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma.Streubel B et al

Summary

Fusion gene

IGH/FOXP1 IGH (14q32.33) FOXP1 (3p13) M t(14;18)(q32;q21) t(1;14)(p22;q32) t(3;14)(p13;q32)

Citation

Jean-Loup Huret

t(3;14)(p14;q32) IGH/FOXP1

Atlas Genet Cytogenet Oncol Haematol. 2005-07-01

Online version: http://atlasgeneticsoncology.org/haematological/1398/t(3;14)(p14;q32)-igh-foxp1

External Links