t(12;17)(p11;q11) in AML

2006-11-01   David Betts 

1.Department of Oncology, University Childrens Hospital, Steinwiesstr. 75, CH-8032 Zò_rich, Switzerland

Clinics and Pathology


Acute myeloid leukaemia (AML)


The appearance of the translocation may resemble the rare non-random t(12;17)(p13;q11-21) associated with ALL.


Very rare translocation reported in three adults and one child with secondary AML following an ALL. The four published cases have been female.


Insufficient data to indicate a prognostic significance.

Genes Involved and Proteins

No report of any molecular or FISH data to elucidate exact breakpoint or genes.


Pubmed IDLast YearTitleAuthors
13846791992Translocations involving 12p in acute myeloid leukemia: association with prior myelodysplasia and exposure to mutagenic agents. United Kingdom Cancer Cytogenetics Group (UKCCG).
129233152003Cytogenetic analysis and clinical significance of chromosome 7 aberrations in acute leukaemia.Brozek I et al
111653152001Acute leukemia cytogenetics: an evaluation of combining G-band karyotyping with multi-color spectral karyotyping.Kerndrup GB et al
23316741990Use of conditioned media in cell culture can mask cytogenetic abnormalities in acute leukemia.Sun GX et al


David Betts

t(12;17)(p11;q11) in AML

Atlas Genet Cytogenet Oncol Haematol. 2006-11-01

Online version: http://atlasgeneticsoncology.org/haematological/1437/t(12;17)(p11;q11)-in-aml