t(12;17)(p11;q11) in AML

2006-11-01   David Betts 

1.Department of Oncology, University Childrens Hospital, Steinwiesstr. 75, CH-8032 Zò_rich, Switzerland

Clinics and Pathology

Disease

Acute myeloid leukaemia (AML)

Note

The appearance of the translocation may resemble the rare non-random t(12;17)(p13;q11-21) associated with ALL.

Epidemiology

Very rare translocation reported in three adults and one child with secondary AML following an ALL. The four published cases have been female.

Prognosis

Insufficient data to indicate a prognostic significance.

Genes Involved and Proteins

Note
No report of any molecular or FISH data to elucidate exact breakpoint or genes.

Bibliography

Pubmed IDLast YearTitleAuthors
13846791992Translocations involving 12p in acute myeloid leukemia: association with prior myelodysplasia and exposure to mutagenic agents. United Kingdom Cancer Cytogenetics Group (UKCCG).
129233152003Cytogenetic analysis and clinical significance of chromosome 7 aberrations in acute leukaemia.Brozek I et al
111653152001Acute leukemia cytogenetics: an evaluation of combining G-band karyotyping with multi-color spectral karyotyping.Kerndrup GB et al
23316741990Use of conditioned media in cell culture can mask cytogenetic abnormalities in acute leukemia.Sun GX et al

Citation

David Betts

t(12;17)(p11;q11) in AML

Atlas Genet Cytogenet Oncol Haematol. 2006-11-01

Online version: http://atlasgeneticsoncology.org/haematological/1437/t(12;17)(p11;q11)-in-aml

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