t(1;21)(q21;q22) RUNX1/ZNF687

2007-09-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Acute myeloid leukaemia (AML)

Epidemiology

only one case to date, a 1 year old boy with M1 AML

Prognosis

no data

Genes Involved and Proteins

Gene name
ZNF687 (zinc finger protein 687)
Location
1q21.3
Protein description
10 zinc fingers; krueppel C2H2-type zinc-finger protein; transcription factor
Gene name
RUNX1 (runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene))
Location
21q22.12
Protein description
Transcription factor (activator) for various hematopoietic-specific genes, which experssion is limited to hematopoetic stem cells, and endothelial cells and mesenchymal cells in the embryo; core binding factor family member which forms heterodimers with CBFB; binds to the core site 5 PyGPyGGTPy 3 of promotors and enhancers

Result of the Chromosomal Anomaly

Description

5 RUNX1- 3 ZNF687

Bibliography

Pubmed IDLast YearTitleAuthors
168586962006Identification of novel Runx1 (AML1) translocation partner genes SH3D19, YTHDf2, and ZNF687 in acute myeloid leukemia.Nguyen TT et al

Summary

Fusion gene

RUNX1/ZNF687 RUNX1 (21q22.12) ZNF687 (1q21.3) M t(1;21)(q21;q22)|RUNX1/ZNF687 RUNX1 (21q22.12) ZNF687 (1q21.3) TIC
Atlas Image
q21;q22) t(1;21)(q21;q22) G- banding - Courtesy Melanie Zenger and Claudia Haferlach.

Citation

Jean-Loup Huret

t(1;21)(q21;q22) RUNX1/ZNF687

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/haematological/1446/t(1;21)(q21;q22)

External Links