t(1;21)(p35;q22) RUNX1/YTHDF2

2007-09-01   Jean-Loup Huret  

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Acute myeloid leukaemia (AML)

Epidemiology

Only one case to date, a 68 year old male patient with M2 AML.

Prognosis

No data.

Genes Involved and Proteins

Gene name
YTHDF2 (YTH N6-methyladenosine RNA binding protein 2)
Location
1p35.3
Protein description
Possible role in immune response.
Gene name
RUNX1 (runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene))
Location
21q22.12
Protein description
Transcription factor (activator) for various hematopoietic-specific genes, which expression is limited to hematopoetic stem cells, endothelial cells and mesenchymal cells in the embryo; core binding factor family member which forms heterodimers with CBFB; binds to the core site 5 PyGPyGGTPy 3 of promotors and enhancers.

Result of the Chromosomal Anomaly

Description

5 RUNX1 - 3 YTHDF2

Article Bibliography

Pubmed IDLast YearTitleAuthors
168586962006Identification of novel Runx1 (AML1) translocation partner genes SH3D19, YTHDf2, and ZNF687 in acute myeloid leukemia.Nguyen TT et al

Summary

Fusion gene

RUNX1/YTHDF2 RUNX1 (21q22.12) YTHDF2 (1p35.3) M t(1;21)(p35;q22)|RUNX1/YTHDF2 RUNX1 (21q22.12) YTHDF2 (1p35.3) TIC

Citation

Jean-Loup Huret

t(1;21)(p35;q22) RUNX1/YTHDF2

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/haematological/1447/teaching-explorer/js/haematological-explorer/