t(12;19)(p13;p13) TCF3/ZNF384

2007-11-01   Roberta La Starza , Cristina Mecucci , Paolo Gorello 

1.Hematology, University of Perugia, via Brunamonti, 06122 Perugia, Italy

Clinics and Pathology

Disease

Acute lymphoblastic leukemia.

Phenotype stem cell origin

Pro-B acute lymphoblastic leukemia with expression of myeloid antigens.

Prognosis

Relatively good prognosis.

Genes Involved and Proteins

Gene name
ZNF384 (Zinc Finger protein 384)
Location
12p13.31
Protein description
Belongs to the Kruppel C2H2-type zinc-finger protein family; contains 8 C2H2-type zinc fingers. Nucleocytoplasmic shuttling protein and transcription factor.
Gene name
TCF3 (transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47))
Location
19p13.3
Note
TCF3

Result of the Chromosomal Anomaly

Description

5 TCF3 - 3 ZNF384

Highly cited references

Pubmed IDYearTitleCitations
343952832021Leukemia With TCF3-ZNF384 Rearrangement as a Distinct Subtype of Disease With Distinct Treatments: Perspectives From A Case Report and Literature Review.0
354093912022Lineage Conversion in Pediatric B-Cell Precursor Acute Leukemia under Blinatumomab Therapy.0
339883072021Systematic application of fluorescence in situ hybridization and immunophenotype profile for the identification of ZNF384 gene rearrangements in B cell acute lymphoblastic leukemia.1
338344632021[Identification of TCF3-ZNF384 fusion by transcriptome sequencing in B cell acute lymphoblastic leukemia and its laboratory and clinical characteristics].0
315758522019Characterization of TCF3 rearrangements in pediatric B-lymphoblastic leukemia/lymphoma by mate-pair sequencing (MPseq) identifies complex genomic rearrangements and a novel TCF3/TEF gene fusion.1
326098262020Shared D-J rearrangements reveal cell of origin of TCF3-ZNF384 and PTPN11 mutations in monozygotic twins with concordant BCP-ALL.2
313477692019Very late relapse cases of TCF3-ZNF384-positive acute lymphoblastic leukemia.5
297976592018Myeloid lineage switch following chimeric antigen receptor T-cell therapy in a patient with TCF3-ZNF384 fusion-positive B-lymphoblastic leukemia.26
283951182017ETV6/RUNX1-like acute lymphoblastic leukemia: A novel B-cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype.24
276342052017ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype.52

Bibliography

Pubmed IDLast YearTitleAuthors
120670682001Involvement of the nuclear matrix in the control of skeletal genes: the NMP1 (YY1), NMP2 (Cbfa1), and NMP4 (Nmp4/CIZ) transcription factors.Bidwell JP et al
168689672006Identification in human osteoarthritic chondrocytes of proteins binding to the novel regulatory site AGRE in the human matrix metalloprotease 13 proximal promoter.Fan Z et al
165101392006Interaction partners for human ZNF384/CIZ/NMP4--zyxin as a mediator for p130CAS signaling?Janssen H et al
157815762005Identifying genes that regulate bone remodeling as potential therapeutic targets.Krane SM et al
159908652005CIZ gene rearrangements in acute leukemia: report of a diagnostic FISH assay and clinical features of nine patients.La Starza R et al
123597452002Recurrent rearrangement of the Ewing's sarcoma gene, EWSR1, or its homologue, TAF15, with the transcription factor CIZ/NMP4 in acute leukemia.Martini A et al

Summary

Fusion gene

TCF3/ZNF384 TCF3 (19p13.3) ZNF384 (12p13.31) M t(12;19)(p13;p13)|TCF3/ZNF384 TCF3 (19p13.3) ZNF384 (12p13.31) TIC
Atlas Image
A) schematic representation of the reciprocal t(12;19)(p13;p13) translocation; B) Break-a-part FISH: RP11-369N23 maps telomeric to the 3ZNF384 while RP11-101F21 partially overlaps with the 5 end of ZNF384 (RP11 clones belong to the Peter De Jong library and were kindly provided by M Rocchi).

Citation

Roberta La Starza ; Cristina Mecucci ; Paolo Gorello

t(12;19)(p13;p13) TCF3/ZNF384

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/haematological/1460/t(12;19)(p13;p13)-tcf3-znf384

External Links