t(13;19)(q14;p13) TCF3/?

2011-08-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


B cell acute lymphoblastic leukemia (B-ALL)


An apparently identical t(13;19)(q14;p13) has been described in 3 cases of chronic lymphocytic leukemia (CLL) (Finn et al., 1998; Merup et al., 1998; Brown et al.,1993).


Only one case to date of ALL with this translocation, a 19-year-old female patient with pre-B-ALL; she achieved complete remission and (CR) was in continuing CR 10 months later, at last follow up (Barber et al., 2007).

Genes Involved and Proteins

The translocation involves TCF3 and an unknown partner.
Gene name
TCF3 (transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47))
Protein description
The E2A gene encodes two distinct basic helix-loop-helix transcription factors, E12 (ITF1) and E47 (TCF3) through alternative splicing. It forms homodimers and heterodimers with other basic helix-loop-helix transcription factors. Ubiquitously expressed during development. Role in cell growth, cell commitment, and differentiation. Role in epithelial mesenchymal transition (review in Slattery et al., 2008).

Highly cited references

Pubmed IDYearTitleCitations
324671452021Philadelphia-like acute lymphoblastic leukemia is associated with minimal residual disease persistence and poor outcome. First report of the minimal residual disease-oriented GIMEMA LAL1913.13
342505042021Clinical significance of novel subtypes of acute lymphoblastic leukemia in the context of minimal residual disease-directed therapy.12
338958092021Molecular classification improves risk assessment in adult BCR-ABL1-negative B-ALL.7
328820242021Genome-Wide Association Study of Susceptibility Loci for TCF3-PBX1 Acute Lymphoblastic Leukemia in Children.5
324323812020Gene regulation could be attributed to TCF3 and other key transcription factors in the muscle of pubertal heifers.5
345974662022Clonal dynamics in pediatric B-cell precursor acute lymphoblastic leukemia with very early relapse.4
333865962021The role of minimal residual disease in specific subtypes of pediatric acute lymphoblastic leukemia.4
331649842020Pharmacogenomics of intracellular methotrexate polyglutamates in patients' leukemia cells in vivo.4
346583082021Transcription factor 3 (TCF3) combined with histone deacetylase 3 (HDAC3) down-regulates microRNA-101 to promote Burkitt lymphoma cell proliferation and inhibit apoptosis.3
350844342022Association of Genetic Ancestry With the Molecular Subtypes and Prognosis of Childhood Acute Lymphoblastic Leukemia.3
346172712022Epstein-Barr virus status of sporadic Burkitt lymphoma is associated with patient age and mutational features.3
350652542022Identification of three immune subtypes characterized by distinct tumor immune microenvironment and therapeutic response in stomach adenocarcinoma.2
349333432022Whole-transcriptome analysis in acute lymphoblastic leukemia: a report from the DFCI ALL Consortium Protocol 16-001.2
340349132021Clinical features and prognostic impact of TCF3-PBX1 in childhood acute lymphoblastic leukemia: A single-center retrospective study of 837 patients from China.2
347287842021Decreased expression of ATF3, orchestrated by β-catenin/TCF3, miR-17-5p and HOXA11-AS, promoted gastric cancer progression via increased β-catenin and CEMIP.2
350656802022Targeting PARP proteins in acute leukemia: DNA damage response inhibition and therapeutic strategies.2
341758972021TCF3 is epigenetically silenced by EZH2 and DNMT3B and functions as a tumor suppressor in endometrial cancer.2
343164062021Gene expression during THP-1 differentiation is influenced by vitamin D3 and not vibrational mechanostimulation.2
344795572021RNA sequencing of blood in coronary artery disease: involvement of regulatory T cell imbalance.2
342784642021Expression of TCF3 in Wilms' tumor and its regulatory role in kidney tumor cell viability, migration and apoptosis in vitro.2
337502582021Genomic landscape of B-other acute lymphoblastic leukemia in an adult retrospective cohort with a focus on BCR-ABL1-like subtype.2
350334482022Overexpression of transcription factor 3 drives hepatocarcinoma development by enhancing cell proliferation via activating Wnt signaling pathway.1
354015012022Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.1
353284872022Resistance Mechanisms in Pediatric B-Cell Acute Lymphoblastic Leukemia.1
344601332022Cryptic TCF3 fusions in childhood leukemia: Detection by RNA sequencing.1
339601012022Construction of circRNA-miRNA-mRNA network in the pathogenesis of recurrent implantation failure using integrated bioinformatics study.1
342334492021Aurora A kinase as a target for therapy in TCF3-HLF rearranged acute lymphoblastic leukemia.1
345494162022Prognostic heterogeneity of adult B-cell precursor acute lymphoblastic leukaemia patients with t(1;19)(q23;p13)/TCF3-PBX1 treated with measurable residual disease-oriented protocols.1
346240792022SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma.1
344556142021MEX3D is an oncogenic driver in prostate cancer.1
344067032021The clinical outcomes and genomic landscapes of acute lymphoblastic leukemia patients with E2A-PBX1: A 10-year retrospective study.1
341837322021Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification.1
348885892021Reframing Burkitt lymphoma: virology not epidemiology defines clinical variants.1
329670042021Epigenome-wide analysis identifies genes and pathways linked to acoustic cry variation in preterm infants.1
339883072021Systematic application of fluorescence in situ hybridization and immunophenotype profile for the identification of ZNF384 gene rearrangements in B cell acute lymphoblastic leukemia.1
336402842021Successful Treatment of TCF3-HLF-positive Childhood B-ALL with Chimeric Antigen Receptor T-Cell Therapy.1
332677332021Thyroid Hormone Receptor α1 Mutants Impair B Lymphocyte Development in a Mouse Model.1
338162702021The Prognostic Significance of ZNF384 Fusions in Adult Ph-Negative B-Cell Precursor Acute Lymphoblastic Leukemia: A Comprehensive Cohort Study From a Single Chinese Center.1
336882372021Whole-Exome Sequencing in Patients Affected by Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Reveals New Variants Potentially Contributing to the Phenotype.1
332441172020Spontaneous intake of essential oils after a negative postnatal experience has long-term effects on blood transcriptome in chickens.1
320030492020Tcf3-activated lncRNA Gas5 regulates newborn mouse cardiomyocyte apoptosis in diabetic cardiomyopathy.1
360018602022TCF3-HLF-Positive Acute Lymphoblastic Leukemia Resembling Burkitt Leukemia: Cell Morphologic and Immunophenotypic Findings.0
359765392022A case of progressive multifocal leukoencephalopathy with hypogammaglobulinemia and a TCF3 mutation.0
359215452022Zinc finger protein 384 (ZNF384) impact on childhood mixed phenotype acute leukemia and B-cell precursor acute lymphoblastic leukemia.0
357096672022Mixed model-based eQTL analysis reveals lncRNAs associated with regulation of genes involved in sex determination and spermatogenesis: The key to understanding human gender imbalance.0
353444692022Adult acute lymphoblastic leukemia in a resource-constrained setting: outcomes after expansion of genetic evaluation.0
360112852022Commonly Assessed Markers in Childhood BCP-ALL Diagnostic Panels and Their Association with Genetic Aberrations and Outcome Prediction.0
359673402022Transcriptional dynamics and epigenetic regulation of E and ID protein encoding genes during human T cell development.0
359070392022Clonal evolution in adult TCF3::HLF-positive acute lymphoblastic leukemia undergoing stem cell transplantation.0
358829372022Exploiting gene dependency to inform drug development for multiple myeloma.0
35782267202218F-FDG PET/CT for the detection of extensive bone relapse in acute lymphoblastic leukemia with TCF3-PBX1 fusion after hematopoietic stem cell transplantation.0
357199522022Underexpression of LINC00173 in TCF3/PBX1-Positive Cases Is Associated With Poor Prognosis in Children With B-Cell Precursor Acute Lymphoblastic Leukemia.0
354460022022TCF3 Induces DNMT1 Expression to Regulate Wnt Signaling Pathway in Glioma.0
356175272022TCF3 protein was highly expressed in pediatric Burkitt lymphoma and predicts poor prognosis: a single-center study.0
355876042022Transcriptional factor 3 binds to sirtuin 1 to activate the Wnt/β-catenin signaling in cervical cancer.0
351343162022Bioinformatics analysis deciphering the transcriptomic signatures associated with signalling pathways and prognosis in the myelodysplastic syndromes.0
353891612022Ciliary and immune dysfunctions and their genetic background in patients with non-cystic fibrosis bronchiectasis in Central Iran.0
348713732022Impact of high-risk cytogenetics on outcomes for children and young adults receiving CD19-directed CAR T-cell therapy.0
356570562022Assessment of gene expressions from squamous cell carcinoma of the head and neck to predict radiochemotherapy-related xerostomia and dysphagia.0
352998892022PTBP1 is a Novel Poor Prognostic Factor for Glioma.0
350292802022NOX4 stimulates ANF secretion via activation of the Sirt1/Nrf2/ATF3/4 axis in hypoxic beating rat atria.0
357014092022ID proteins promote the survival and primed-to-naive transition of human embryonic stem cells through TCF3-mediated transcription.0
356859212022Low Prevalence of ETV6::RUNX1 Fusion Gene in a Hispanic Population.0
351257242022Incidence and Prognostic Impact of TCF3-PBX1 Fusion in Childhood Acute Lymphoblastic Leukemia: A Single Centre Experience.0
355629652022Multi-Cohort Transcriptomic Subtyping of B-Cell Acute Lymphoblastic Leukemia.0
354093912022Lineage Conversion in Pediatric B-Cell Precursor Acute Leukemia under Blinatumomab Therapy.0
352395102022TCF3 regulates human endometrial stromal cell proliferation and migration in RPL.0
350926532022MicroRNA gene methylation landscape in pediatric B-cell precursor acute lymphoblastic leukemia.0
346183072022Primary antibody deficiencies in Turkey: molecular and clinical aspects.0
346174332022Characterization of Immunophenotypic Aberrancies with Respect to Common Fusion Transcripts in B-Cell Precursor Acute Lymphoblastic Leukemia: A Report of 986 Indian Patients0
343250572021Comparison of Two Quantitative PCR-Based Assays for Detection of Minimal Residual Disease in B-Precursor Acute Lymphoblastic Leukemia Harboring Three Major Fusion Transcripts.0
350844772022Metabolic path toward TCF3 inactivation in Burkitt lymphoma.0
350785772022[T cell factor 3 (TCF3) is overexpressed in hepatocellular carcinoma and promotes their invasion and metastasis].0
347003722022The miR526b-5p-Related Single Nucleotide Polymorphisms, rs72618599, Located in 3'-UTR of TCF3 Gene, is Associated with the Risk of Breast and Gastric Cancers0
345538422021Genetic features of B-cell lymphoblastic lymphoma with TCF3-PBX1.0
349665752021A transcription factor signature predicts the survival of patients with adrenocortical carcinoma.0
340497152021Expression of BCL6 in paediatric B-cell acute lymphoblastic leukaemia and association with prognosis.0
345274462021Prognostic impact of a lymphocyte activation-associated gene signature in GBM based on transcriptome analysis.0
345131002021Intermediate between Idiopathic Hypereosinophilia and Chronic Eosinophilic Leukemia: A Report of Two Hypereosinophilic Cases with Possible Novel Molecular Mutations.0
349468752021Genome-Wide Selective Signatures Reveal Candidate Genes Associated with Hair Follicle Development and Wool Shedding in Sheep.0
347716462021Towards Raman-Based Screening of Acute Lymphoblastic Leukemia-Type B (B-ALL) Subtypes.0
337253182021Clinical features and chromosomal/genetic aberration in adult acute lymphoblastic leukemia in Japan: results of Fukuoka Blood & Marrow Transplant Group Studies ALL MRD 2002 and 2008.0
358451832021Cytogenetic aberrations in adult acute lymphoblastic leukemia-A population-based study.0
344228202021TCF3 Regulates the Proliferation and Apoptosis of Human Spermatogonial Stem Cells by Targeting PODXL.0
341594012021Hematological characteristics, cytogenetic features, and post-induction measurable residual disease in thymic stromal lymphopoietin receptor (TSLPR) overexpressed B-cell acute lymphoblastic leukemia in an Indian cohort.0
339050482021TCF3 Dominant Negative Variant Causes an Early Block in B-Lymphopoiesis and Agammaglobulinemia.0
343952832021Leukemia With TCF3-ZNF384 Rearrangement as a Distinct Subtype of Disease With Distinct Treatments: Perspectives From A Case Report and Literature Review.0
338907262021CRLF2 and IKZF1 abnormalities in Mexican children with acute lymphoblastic leukemia and recurrent gene fusions: exploring surrogate markers of signaling pathways.0
339879752021Subgrouping by gene expression profiles to improve relapse risk prediction in paediatric B-precursor acute lymphoblastic leukaemia.0
336760402021Corrigendum to "TCF3-activated FAM201A enhances cell proliferation and invasion via miR-186-5p/TNKS1BP1 axis in triple-negative breast cancer" [Bioorg. Chem. 104 (2020) 104301].0
343483052021Cytogenetic and Fluorescence in situ Hybridization Profile of Pediatric Acute Lymphoblastic Leukemia in a University Hospital in South India.0
341761122021Src-IL-18 signaling regulates the secretion of atrial natriuretic factor in hypoxic beating rat atria.0
339692762021Acquisition of TCF3 and CCND3 Mutations and Transformation to Burkitt Lymphoma in a Case of B-Cell Prolymphocytic Leukemia.0
338344632021[Identification of TCF3-ZNF384 fusion by transcriptome sequencing in B cell acute lymphoblastic leukemia and its laboratory and clinical characteristics].0
332837062020[The Correlation of Minimal Residual Disease with Prognosis in TCF3-PBX1+ Acute Lymphoblastic Leukemia in Children].0
336463062021Genome-wide interference of ZNF423 with B-lineage transcriptional circuitries in acute lymphoblastic leukemia.0
336028722021XPO7 is a tumor suppressor regulating p21CIP1-dependent senescence.0
336630972021Co-occurrence of TCF3-PBX1 gene fusion, and chromosomal aberration in a pediatric pre-B cell acute lymphoblastic leukemia with clitoris swelling: A case report and literature review.0
336233762021Identification and Characterisation of Putative Enhancer Elements in Mouse Embryonic Stem Cells.0
332211502021Long-Term Results of the Risk-Stratified Treatment of TCF3-PBX1-Positive Pediatric Acute Lymphoblastic Leukemia in China.0


Pubmed IDLast YearTitleAuthors
173113192007Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia.Barber KE et al
84906581993Evidence for a new tumour suppressor locus (DBM) in human B-cell neoplasia telomeric to the retinoblastoma gene.Brown AG et al
97986601998Secondary abnormalities of chromosome 6q in B-cell chronic lymphocytic leukemia: a sequential study of karyotypic instability in 51 patients.Finn WG et al
97421201998The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF.Inukai T et al
95932681998A FISH cosmid 'cocktail' for detection of 13q deletions in chronic lymphocytic leukaemia--comparison with cytogenetics and Southern hybridization.Merup M et al
176042082008E2A proteins: regulators of cell phenotype in normal physiology and disease.Slattery C et al


Jean-Loup Huret

t(13;19)(q14;p13) TCF3/?

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/haematological/1512/t(13;19)(q14;p13)