t(13;19)(q14;p13) TCF3/?

2011-08-01   Jean-Loup Huret  

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

B cell acute lymphoblastic leukemia (B-ALL)

Note

An apparently identical t(13;19)(q14;p13) has been described in 3 cases of chronic lymphocytic leukemia (CLL) (Finn et al., 1998; Merup et al., 1998; Brown et al.,1993).

Epidemiology

Only one case to date of ALL with this translocation, a 19-year-old female patient with pre-B-ALL; she achieved complete remission and (CR) was in continuing CR 10 months later, at last follow up (Barber et al., 2007).

Genes Involved and Proteins

Note
The translocation involves TCF3 and an unknown partner.
Gene name
TCF3 (transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47))
Location
19p13.3
Protein description
The E2A gene encodes two distinct basic helix-loop-helix transcription factors, E12 (ITF1) and E47 (TCF3) through alternative splicing. It forms homodimers and heterodimers with other basic helix-loop-helix transcription factors. Ubiquitously expressed during development. Role in cell growth, cell commitment, and differentiation. Role in epithelial mesenchymal transition (review in Slattery et al., 2008).

Highly cited references

Pubmed IDYearTitleCitations
219036722011Maintaining embryonic stem cell pluripotency with Wnt signaling.135
259908632015Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia.128
322557082020Burkitt lymphoma: bridging the gap between advances in molecular biology and therapy.115
330389822020Molecular markers in ALL: Clinical implications.107
209513442010Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification.101
274476722016TCF/LEF Transcription Factors: An Update from the Internet Resources.90
393773972024Integrated multi-omics analysis of PBX1 in mouse adult neural stem- and progenitor cells identifies a transcriptional module that functionally links PBX1 to TCF3/4.89
319020362020Insights into the prenatal origin of childhood acute lymphoblastic leukemia.82
373067222023ZNF384-Related Fusion Genes in Acute Lymphoblastic Leukemia.81
376846872023Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon.78
363309282022ID1 and CEBPA coordinate epidermal progenitor cell differentiation.74
360112852022Commonly Assessed Markers in Childhood BCP-ALL Diagnostic Panels and Their Association with Genetic Aberrations and Outcome Prediction.74
249098262014Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2.70
248325382014Tcf3 represses Wnt-β-catenin signaling and maintains neural stem cell population during neocortical development.70
293169062018The function of tcf3 in medaka embryos: efficient knockdown with pePNAs.69
344228202021TCF3 Regulates the Proliferation and Apoptosis of Human Spermatogonial Stem Cells by Targeting PODXL.67
366056212023Netrin-1 mediates nerve innervation and angiogenesis leading to discogenic pain.67
364432972022A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation.63
244928472014Oncogenic mechanisms in Burkitt lymphoma.61
215470582011Fishing pluripotency mechanisms in vivo.60
382871032024Id2 epigenetically controls CD8(+) T-cell exhaustion by disrupting the assembly of the Tcf3-LSD1 complex.57
380102892024LncRNA-CCAT5-mediated crosstalk between Wnt/β-Catenin and STAT3 signaling suggests novel therapeutic approaches for metastatic gastric cancer with high Wnt activity.57
366314352023Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma.56
348713732022Impact of high-risk cytogenetics on outcomes for children and young adults receiving CD19-directed CAR T-cell therapy.55
383387542024CircRNAome of Childhood Acute Lymphoblastic Leukemia: Deciphering Subtype-Specific Expression Profiles and Involvement in TCF3::PBX1 ALL.54
191765872009Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression.54
377219712023Transcription Factor TCF3 Promotes Macrophage-Mediated Inflammation and MMP Secretion in Abdominal Aortic Aneurysm by Regulating miR-143-5p /CCL20.53
385120212024Distinct Regulation of ASCL1 by the Cell Cycle and Chemotherapy in Small Cell Lung Cancer.48
392056422024TCF3 as a multidimensional biomarker: oncogenicity, genomic alterations, and immune landscape in pan-cancer analysis.46
228856992012Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics.44
344556142021MEX3D is an oncogenic driver in prostate cancer.43
282114722017Proteolysis regulates cardiomyocyte maturation and tissue integration.43
346240792022SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma.42
368291812023CMTM7 inhibits breast cancer progression by regulating Wnt/β-catenin signaling.42
371004572023Senescence-related genes define prognosis, immune contexture, and pharmacological response in gastric cancer.42
376909942024A genetic variant in the immune-related gene ERAP1 affects colorectal cancer prognosis.41
380582092024PELI2 regulates early B-cell progenitor differentiation and related leukemia via the IL-7R expression.40
336028722021XPO7 is a tumor suppressor regulating p21(CIP1)-dependent senescence.39
271661932016Repression of TCF3/E2A contributes to Hodgkin lymphomagenesis.38
250380422014Tcf3 expression marks both stem and progenitor cells in multiple epithelia.37
372770742023TCF3 haploinsufficiency defined by immune, clinical, gene-dosage, and murine studies.36
253752192014Hypomethylation-associated up-regulation of TCF3 expression and recurrence in stage II and III colorectal cancer.36
378672222023Transcription Factor Id1 Plays an Essential Role in Th9 Cell Differentiation by Inhibiting Tcf3 and Tcf4.34
346583082021Transcription factor 3 (TCF3) combined with histone deacetylase 3 (HDAC3) down-regulates microRNA-101 to promote Burkitt lymphoma cell proliferation and inhibit apoptosis.34
216858942011Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal.33
342784642021Expression of TCF3 in Wilms' tumor and its regulatory role in kidney tumor cell viability, migration and apoptosis in vitro.33
274610632017Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia.32
304872232018Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases.31
385157082024EP300 regulates the SLC16A1-AS1-AS1/TCF3 axis to promote lung cancer malignancies through the Wnt signaling pathway.29
315584682019The whole-genome landscape of Burkitt lymphoma subtypes.28
324494352020Burkitt lymphoma-related TCF3 mutations alter TCF3 alternative splicing by disrupting hnRNPH1 binding.27
325639102020Ibrutinib is not an effective drug in primografts of TCF3-PBX1.27
345538422022Genetic features of B-cell lymphoblastic lymphoma with TCF3-PBX1.27
365769462023Identification of TCF3 germline variants in pediatric B-cell acute lymphoblastic leukemia.25
346315022021Increased expression of TCF3, transcription factor 3, is a defense response against methylmercury toxicity in mouse neuronal C17.2 cells.24
315758522019Characterization of TCF3 rearrangements in pediatric B-lymphoblastic leukemia/lymphoma by mate-pair sequencing (MPseq) identifies complex genomic rearrangements and a novel TCF3/TEF gene fusion.23
322453832020Comprehensive chromosomal aberrations in a case of a patient with TCF3-HLF-positive BCP-ALL.23
351257242022Incidence and Prognostic Impact of TCF3-PBX1 Fusion in Childhood Acute Lymphoblastic Leukemia: A Single Centre Experience.20
302625662019B-lymphoblastic lymphoma with TCF3-PBX1 fusion gene.19
360018602022TCF3-HLF-Positive Acute Lymphoblastic Leukemia Resembling Burkitt Leukemia: Cell Morphologic and Immunophenotypic Findings.16
384262882024Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia.15
323914172020Targeting the oncogenic activity of TCF3-HLF in leukemia.10
301813582018Alternative pre-mRNA splicing switch controls hESC pluripotency and differentiation.9
373920462023TCF3::HLF acute lymphoblastic leukemia: still challenging to cure thirty years later.5
379956822023Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies.0
388399782024Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators.0
381060882023SINGLE CELL DISSECTION OF DEVELOPMENTAL ORIGINS AND TRANSCRIPTIONAL HETEROGENEITY IN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA.0
374073632023Transcription factor abnormalities in B-ALL leukemogenesis and treatment.0
350844772022Metabolic path toward TCF3 inactivation in Burkitt lymphoma.0
278888842016Update on Burkitt Lymphoma.0
370583242023TCF3 gene rearrangements in pediatric B-cell acute lymphoblastic leukemia-A single center experience.0
383035152024Transcription factor 3 is dysregulated in megakaryocytes in myelofibrosis.0
221962142012WNTing embryonic stem cells.0
354460022022TCF3 Induces DNMT1 Expression to Regulate Wnt Signaling Pathway in Glioma.0
391825682024RNA-binding protein LSM7 facilitates breast cancer metastasis through mediating alternative splicing of CD44.0
388399772024TCF3, TCF12 and distinct enhancers regulate oocyte transcription.0
344601332022Cryptic TCF3 fusions in childhood leukemia: Detection by RNA sequencing.0
352395102022TCF3 regulates human endometrial stromal cell proliferation and migration in RPL.0
274315732016Regulation of the miRNA expression by TEL/AML1, BCR/ABL, MLL/AF4 and TCF3/PBX1 oncoproteins in acute lymphoblastic leukemia (Review).0
386833922024B-cells absence in patients diagnosed as inborn errors of immunity: a registry-based study.0
320030492020Tcf3-activated lncRNA Gas5 regulates newborn mouse cardiomyocyte apoptosis in diabetic cardiomyopathy.0
293342552018NGS-based methylation profiling differentiates TCF3-HLF and TCF3-PBX1 positive B-cell acute lymphoblastic leukemia.0
366519502023Protocatechuic Aldehyde Alleviates d -Galactose-Induced Cardiomyocyte Senescence by Regulating the TCF3/ATG5 Axis.0
371299182024Rare TCF3 variants associated with pediatric B cell acute lymphoblastic leukemia.0
362082462022[Expression of TCF3 in Burkitt's Lymphoma and Its Proliferative Effect and Prognostic Significance].0
340349132021Clinical features and prognostic impact of TCF3-PBX1 in childhood acute lymphoblastic leukemia: A single-center retrospective study of 837 patients from China.0
391457792024CD19 CAR T-cell therapy in relapsed TCF3-HLF-positive B-cell acute lymphoblastic leukemia.0
356175272022TCF3 protein was highly expressed in pediatric Burkitt lymphoma and predicts poor prognosis: a single-center study.0
350785772022[T cell factor 3 (TCF3) is overexpressed in hepatocellular carcinoma and promotes their invasion and metastasis].0
332211502021Long-Term Results of the Risk-Stratified Treatment of TCF3-PBX1-Positive Pediatric Acute Lymphoblastic Leukemia in China.0
284365812017Pediatric acute lymphoblastic leukemia with t(1;19)/TCF3-PBX1 in Taiwan.0
387197702024Evaluation of next-generation sequencing for measurable residual disease monitoring in three major fusion transcript subtypes of B-precursor acute lymphoblastic leukaemia.0
393069172024Dysregulation of metallothionein MT1 sub-types in TCF3::PBX1 pre-B-cell acute lymphoblastic leukemia.0
271053232016Transcription factor 3 controls cell proliferation and migration in glioblastoma multiforme cell lines.0
286044572017Up-regulation of Transcription Factor 3 Is Correlated With Poor Prognosis in Cervical Carcinoma.0
359765392022A case of progressive multifocal leukoencephalopathy with hypogammaglobulinemia and a TCF3 mutation.0
281076082017The increased expression of TCF3 is correlated with poor prognosis in Chinese patients with nasopharyngeal carcinoma.0
359070392022Clonal evolution in adult TCF3::HLF-positive acute lymphoblastic leukemia undergoing stem cell transplantation.0
300516462018Excellent outcome of acute lymphoblastic leukaemia with TCF3-PBX1 rearrangement in Hong Kong.0
282139172017Solid pseudopapillary neoplasm expresses inhibin-α and Tcf-3.0

Article Bibliography

Pubmed IDLast YearTitleAuthors
173113192007Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia.Barber KE et al
84906581993Evidence for a new tumour suppressor locus (DBM) in human B-cell neoplasia telomeric to the retinoblastoma gene.Brown AG et al
97986601998Secondary abnormalities of chromosome 6q in B-cell chronic lymphocytic leukemia: a sequential study of karyotypic instability in 51 patients.Finn WG et al
97421201998The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF.Inukai T et al
95932681998A FISH cosmid 'cocktail' for detection of 13q deletions in chronic lymphocytic leukaemia--comparison with cytogenetics and Southern hybridization.Merup M et al
176042082008E2A proteins: regulators of cell phenotype in normal physiology and disease.Slattery C et al

Citation

Jean-Loup Huret

t(13;19)(q14;p13) TCF3/?

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/haematological/1512/t(13;19)(q14;p13)