t(7;21)(p15;q22) RUNX1/?

2008-09-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

De novo acute myeloid leukemia (AML), type M2 with monocytosis or M4 in the case tested for RUNX1. Other cases presented with a chronic myelomonocytic leukemia evolving towards a M4-AML which may be therapy related, and with a M3-AML (promyelocytic leukemia) with t(15;17).

Epidemiology

Only three cases to date, 2 male and 1 female patients, aged 46, 70, ? (Koo et al., 1998; Jeandidier et al., 2006).

Genes Involved and Proteins

Note
The partner of RUNX1 is unknown.
Gene name
RUNX1 (runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene))
Location
21q22.12
Protein description
Contains a Runt domain and, in the C-term, a transactivation domain; forms heterodimers; widely expressed; nuclear localisation; transcription factor (activator) for various hematopoietic-specific genes.

Bibliography

Pubmed IDLast YearTitleAuthors
166161062006Abnormalities of the long arm of chromosome 21 in 107 patients with hematopoietic disorders: a collaborative retrospective study of the Groupe Français de Cytogénétique Hématologique.Jeandidier E et al
94604921998Cytogenetic and fluorescence in situ hybridization analyses of hematologic malignancies in Korea.Koo SH et al

Citation

Jean-Loup Huret

t(7;21)(p15;q22) RUNX1/?

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/haematological/1526/t(7;21)(p15;q22)

External Links