t(1;6)(p36;p21)

2008-12-01   Jean-Loup Huret  

1.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), but also chronic lymphoproliferative diseases (CLD)

Phenotype stem cell origin

The MDS case was a refractory anaemia with ringed sideroblasts (RARS), the AML case was a treatment related leukaemia (t-AML) (Hirst et al., 1993; Olney et al., 2002). The two CLD cases were chronic lymphocytic leukaemia (CLL) cases, one of which being atypical (Datta et al., 1991; Martin-Subero et al., 2007). This translocation is likely to be heterogenous.

Epidemiology

Only four cases to date; the case with RARS was a 72-year-old male patient, the t-AML case was also a male patient; the CLL cases (1 male and 1 female patients) were aged 35 and 75.

Prognosis

No data.

Genes Involved and Proteins

Note
Genes involved are unknown.

Article Bibliography

Pubmed IDLast YearTitleAuthors
19136071991Chromosome analyses in chronic lymphocytic leukemia and related B-cell neoplasms.Datta T et al
84319161993Consistent interstitial chromosomal deletions in myeloid malignancies and their correlation with fragile sites.Hirst WJ et al
174959772007A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation.Martín-Subero JI et al
119212752002Unique balanced chromosome abnormalities in treatment-related myelodysplastic syndromes and acute myeloid leukemia: report from an international workshop.Olney HJ et al

Citation

Jean-Loup Huret

t(1;6)(p36;p21)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/haematological/1530/t(1;6)(p36;p21)