2008-12-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


Myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), but also chronic lymphoproliferative diseases (CLD)

Phenotype stem cell origin

The MDS case was a refractory anaemia with ringed sideroblasts (RARS), the AML case was a treatment related leukaemia (t-AML) (Hirst et al., 1993; Olney et al., 2002). The two CLD cases were chronic lymphocytic leukaemia (CLL) cases, one of which being atypical (Datta et al., 1991; Martin-Subero et al., 2007). This translocation is likely to be heterogenous.


Only four cases to date; the case with RARS was a 72-year-old male patient, the t-AML case was also a male patient; the CLL cases (1 male and 1 female patients) were aged 35 and 75.


No data.

Genes Involved and Proteins

Genes involved are unknown.


Pubmed IDLast YearTitleAuthors
19136071991Chromosome analyses in chronic lymphocytic leukemia and related B-cell neoplasms.Datta T et al
84319161993Consistent interstitial chromosomal deletions in myeloid malignancies and their correlation with fragile sites.Hirst WJ et al
174959772007A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation.Martín-Subero JI et al
119212752002Unique balanced chromosome abnormalities in treatment-related myelodysplastic syndromes and acute myeloid leukemia: report from an international workshop.Olney HJ et al


Jean-Loup Huret


Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/haematological/1530/t(1;6)(p36;p21)