t(12;19)(q13;q13)

2009-01-01   Jean-Loup Huret  

1.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Phenotype stem cell origin

Myeloid leukaemias (Paietta et al., 1988; Scheurlen et al., 1999), if we exclude a case of lymphoplasmacytoid lymphoma (Offit el al., 1995). The translocation is found in M1-AML and M2-AML, with erythroid hyperplasia in the bone marrow and the presence of binucleated and trinucleated red cells in at least 3 of 4 cases (Paietta et al., 1988).

Epidemiology

Four cases available, 2 male and 2 female patients, aged 26, 61, 63, and 63.

Prognosis

The clinical outcome is poor, with 2 cases not entering into remission and dead within 2 months after diagnosis, and a third patient with partial remission, relapse after 2 months, and death. The fourth patients outcome is unknown.

Genes Involved and Proteins

Note
The genes involved in this translocation are unknown.

Article Bibliography

Pubmed IDLast YearTitleAuthors
76629831995Del (7)(q32) is associated with a subset of small lymphocytic lymphoma with plasmacytoid features.Offit K et al
33959901988Translocation t(12;19)(q13;q13.3). A new recurrent abnormality in acute nonlymphocytic leukemia with atypical erythropoiesis.Paietta E et al
103798691999Mapping of the breakpoints on the short arm of chromosome 17 in neoplasms with an i(17q).Scheurlen WG et al

Citation

Jean-Loup Huret

t(12;19)(q13;q13)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/haematological/1532/t(12;19)(q13;q13)