t(12;19)(q13;q13)

2009-01-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Phenotype stem cell origin

Myeloid leukaemias (Paietta et al., 1988; Scheurlen et al., 1999), if we exclude a case of lymphoplasmacytoid lymphoma (Offit el al., 1995). The translocation is found in M1-AML and M2-AML, with erythroid hyperplasia in the bone marrow and the presence of binucleated and trinucleated red cells in at least 3 of 4 cases (Paietta et al., 1988).

Epidemiology

Four cases available, 2 male and 2 female patients, aged 26, 61, 63, and 63.

Prognosis

The clinical outcome is poor, with 2 cases not entering into remission and dead within 2 months after diagnosis, and a third patient with partial remission, relapse after 2 months, and death. The fourth patients outcome is unknown.

Genes Involved and Proteins

Note
The genes involved in this translocation are unknown.

Bibliography

Pubmed IDLast YearTitleAuthors
76629831995Del (7)(q32) is associated with a subset of small lymphocytic lymphoma with plasmacytoid features.Offit K et al
33959901988Translocation t(12;19)(q13;q13.3). A new recurrent abnormality in acute nonlymphocytic leukemia with atypical erythropoiesis.Paietta E et al
103798691999Mapping of the breakpoints on the short arm of chromosome 17 in neoplasms with an i(17q).Scheurlen WG et al

Citation

Jean-Loup Huret

t(12;19)(q13;q13)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/haematological/1532/t(12;19)(q13;q13)

External Links