t(2;19)(p23;p13) TPM4/ALK

2013-01-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


Only one case to date, an 18-month-old boy with a null-ALCL (Meech et al., 2001).


Cells expressed both myeloid (CD13, CD33, HLA-DR) and natural killer (CD3-/CD56+, germline TCR genes, CD25+/CD122+/granzyme B+) cell antigens.


The patient was in remission 14 months after completion of therapy.

Genes Involved and Proteins

Gene name
ALK (anaplastic lymphoma receptor tyrosine kinase)
Protein description
1620 amino acids; ALK is a membrane associated tyrosine kinase receptor of the insulin receptor superfamily.
Gene name
TPM4 (tropomyosin)
Protein description
248 amino acids; tropomyosins are actin-binding proteins; component of cytoskeletal microfilaments; role in the calcium dependent regulation of striated muscle.

Result of the Chromosomal Anomaly


5TPM4-3ALK. Fusion between TPM4 nucleotide 714 and ALK nucleotide 4084.


Pubmed IDLast YearTitleAuthors
109341422000TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors.Lawrence B et al
114934722001Unusual childhood extramedullary hematologic malignancy with natural killer cell properties that contains tropomyosin 4--anaplastic lymphoma kinase gene fusion.Meech SJ et al
162133622005Detection of ETV6 and RUNX1 gene rearrangements using fluorescence in situ hybridization in Mexican patients with acute lymphoblastic leukemia: experience at a single institution.Pérez-Vera P et al


Fusion gene

TPM4/ALK TPM4 (19p13.12) ALK (2p23.2) COF 441 442|TPM4/ALK TPM4 (19p13.12) ALK (2p23.2) M t(2;19)(p23;p13)|TPM4/ALK TPM4 (19p13.12) ALK (2p23.2) TIC


Jean-Loup Huret

t(2;19)(p23;p13) TPM4/ALK

Atlas Genet Cytogenet Oncol Haematol. 2013-01-01

Online version: http://atlasgeneticsoncology.org/haematological/1549/t(2;19)(p23;p13)-tpm4-alk

External Links