1.Kuwait Cancer control Center, Department of Hematology, Kuwait; email@example.com
Acute promyelocytic leukemia (APL) is characterized by arrest of leukocyte differentiation at the promyelocyte stage. In classic APL, the central leukemia-initiating event is the chromosome translocation t(15;17)(q22;q21) resulting in the fusion of the retinoic acid receptor-alpha (RARA) gene on 17q21.1 with the promyelocytic leukemia (PML) gene at 15q24.1. In rare cases, RARA is fused with genes other than PML that gives rise to APL variants such as in der(2)t(2;17)(q32;q21) with the underlying NABP1/RARA fusion gene.
Atlas Genet Cytogenet Oncol Haematol. 2017-03-01
Online version: http://atlasgeneticsoncology.org/haematological/1601/t(2;17)(q32;q21)-nabp1-rara