t(3;8)(p25;q24)

2018-08-01   Jean-Loup Huret  

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Abstract

Review on t(3;8)(p25;q24), with data on clinics

Clinics and Pathology

Disease

Blastic plasmacytoid dendritic cell neoplasm (BPDCN)

Note

BPDCN has been known with various names, including agranular CD4+ natural killer (NK) leukemia, CD4+/CD56+ hematodermic neoplasm, and blastic NK lymphoma. BPDCN malignant cells are derived from the precursors of plasmacytoid dendritic cells. It most commonly involves the skin. BPDCN is an aggressive neoplasm. BPDCN is often associated with a complex karyotype (review in Meloni-Ehrig 2017).

Epidemiology

In a series of 41 patients with BPDCN, five had a MYC rearrangement confirmed by FISH, one had a t(X;8)(q24;q24), one had a t(3;8)(p25;q24), two had a t(6;8)(p21;q24) MYC/SUPT3H, and one had a t(8;14)(q24.1;q32) (Boddu et al., 2018).

Clinics

The patient with a t(3;8)(p25;q24) was a 66 year-old male patient with skin, lymph nodes and central nervous system involvement. He was alive and well 12 months+ after diagnosis.

Cytogenetics

The karyotype was complex.

Genes Involved and Proteins

Note
The partner gene of MYC is unknown.
Gene name
MYC
Location
8q24.21
Dna rna description
MYC is composed of three exons spanning over 4 kb.
Protein description
MYC is expressed in almost all proliferating cells. It is located predominantly in the nucleus. MYC is a transcriptional regulator, capable to induce or repress the expression of thousands genes. MYC is deregulated in cancer by several different mechanisms: chromosomal translocations, amplifications, point mutations, epigenetic reprogramming, enhanced translation and increased protein stability (review in Mohamed, 2017).

Article Bibliography

Pubmed IDLast YearTitleAuthors
2940758620188q24/MYC rearrangement is a recurrent cytogenetic abnormality in blastic plasmacytoid dendritic cell neoplasms.Boddu PC et al

Citation

Jean-Loup Huret

t(3;8)(p25;q24)

Atlas Genet Cytogenet Oncol Haematol. 2018-08-01

Online version: http://atlasgeneticsoncology.org/haematological/1827/t(3;8)(p25;q24)