Lymphoepithelioid lymphoma

2002-06-01   Gianluigi Castoldi , Antonio Cuneo 

1.Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy

Clinics and Pathology

Phenotype stem cell origin

Peripheral CD4+ T-cell lymphoma

Epidemiology

The disease is rare

Clinics

The patients present superficial lymph node involvement. The cervical areas are predominantly affected, whereas thoracic adenopathies and deep abdominal involvement occur unfrequently at presentation.

Pathology

The disease cannot be separated from the broad category of peripheral T-cell lymphoma (PTL). PTL is characterized by a heterogeneous cellular composition with small and large cells with an inflammarory background. Lennerts lymphoma can be recognized by the presence of numerous epithelioid histiocytes usually grouped in small clusters. Lennerts lymphoma is not considered as a distinct clinicopathological entity.

Treatment

The disease must be treated with multiagent chemotherapy and/or radiation therapy as for other PTL

Evolution

The disease usually runs a relatively aggressive clinical course.

Prognosis

Median survival of 16 to 32 months was reported in some studies

Bibliography

Pubmed IDLast YearTitleAuthors
30817661986Cytogenetic and immunohistochemical analysis of lymphoepithelioid cell lymphoma (Lennert's lymphoma): further substantiation of its T-cell nature.Gödde-Salz E et al
37108221986Cytogenetic studies in non-Hodgkin lymphomas--results from surgical biopsies.Kristoffersson U et al

Citation

Gianluigi Castoldi ; Antonio Cuneo

Lymphoepithelioid lymphoma

Atlas Genet Cytogenet Oncol Haematol. 2002-06-01

Online version: http://atlasgeneticsoncology.org/haematological/2005/lymphoepithelioid-lymphoma

External Links