1.Kaiser Permanente Southern California, 4580 ElectronicPlace, Los Angeles, CA 90039, USA2.Laboratoire Pasteur-Cerba, 95066, Cergy-Pontoise, France
The main immunophenotypic features that define B-CLL are: the predominant population shares B-cell markers CD19, CD20, and CD23 with the CD5 antigen, in the absence of other pan-T-cell markers; the B-cell is monoclonal with regard to expression of either kappa or lambda; and surface immunoglobulin (slg) is of low density. Not only are these characteristics generally adequate for a precise diagnosis, but, importantly, they distinguish CLL from uncommon disorders such as PLL, hairy-cell leukemia, mantle-cell lymphoma, and other lymphomas. Further, the Matutes score based on the most common marker profile in CLL, CD5+, CD23+, FMC7- and weak expression (+/-) of surface immunoglobulin (SIg) and CD22, can distinguish between typical and atypical CLL by assigning scores that range from 5 (typical of CLL) to 0 (atypical for CLL).
Kavita S Reddy
Chronic lymphocytic leukaemia (CLL)
Atlas Genet Cytogenet Oncol Haematol. 2005-05-01
Online version: http://atlasgeneticsoncology.org/haematological/2034/cllid2034
1997-08-01 Chronic lymphocytic leukaemia (CLL) by Jean-Loup Huret,Hossain Mossafa