Cutaneous T-cell lymphomas

2005-05-01   Gianluigi Castoldi , Antonio Cuneo 

1.Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy

Clinics and Pathology

Phenotype stem cell origin

These are peripheral T-cell tumours, usually expressing CD4 along with other T-cell markers. The CD30 molecule is expressed in a histologically distinct subset (vide infra).
Classification: The WHO identifies some well-defined clinicopathological entities with distinct clinical behaviour. Indolent forms include mycosis fungoides, primary cutaneous CD30 (Ki1) positive anaplastic large cell lymphomas and its benign variant lymphomatous papulosis; aggressive forms include Sezarys syndrome and peripheral CD30-negative T-cell lymphoma.

Epidemiology

Primary cutaneous non Hodgkins lymphomas (NHL) has an approximate 0,4/100.000 incidence in the U.S. The majority of patients are between 40 and 60 years old.

Clinics

Details on clinics, pathology, cytogenetics and molecular cytogenetics can be found in disease-specific cards (i.e. mycosis fungoides / Sezarys syndrome, primary cutaneous CD30 positive anaplastic large cell lymphoma).

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Bibliography

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Citation

Gianluigi Castoldi ; Antonio Cuneo

Cutaneous T-cell lymphomas

Atlas Genet Cytogenet Oncol Haematol. 2005-05-01

Online version: http://atlasgeneticsoncology.org/haematological/2035/cutaneous-t-cell-lymphomas

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