t(1;2)(p22;p12) IGK/BCL10
t(1;14)(p22;q32) IGH/BCL10

2001-01-01   Gianluigi Castoldi , Antonio Cuneo 

1.Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy

Clinics and Pathology


the translocation is cytogenetically detectable in a minority of extranodal MALT lymphomas; irrespective of the presence of the 1;14 translocation, mutation or deletion of the BCL10 gene located at 1p22 can be detected by molecular genetic methods in 5-10% of extra-nodal MALT lymphomas, follicle centre cell lymphoma and diffuse large B-cell lymphoma; among MALT lymphoma a preferential association was noted with high-grade histology


in MALT lymphoma there may be an association with aggressive histology and antibiotic-unresponsive forms

Genes Involved and Proteins

the breakpoints on chromosome 1p22 are located upstream of the promoter of the BCL10 gene, which shows inactivating mutations or deletions
Gene name
BCL10 (B-cell CLL/lymphoma 10)
Protein description
322 amino acids; contains a caspase recruitment domain; role in the apoptosis
Gene name
IGH (Immunoglobulin Heavy)

Highly cited references

Pubmed IDYearTitleCitations
208307192011BCL6 gene rearrangement and protein expression are associated with large cell presentation of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue.9
198602122009[Crucial roles of Helicobacter pylori infection in the pathogenesis of gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) lymphoma].1
195760812009[A clinical study of chromosome translocations in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in Chinese patients].0
180401432007MALT lymphoma : recent advances in aetiology and molecular genetics.25
190805372008[High incidence of t (11; 18)/API2-MALT1 and BCL10 aberrant nuclear expression in pulmonary mucosa-associated lymphoid tissue lymphomas].0
189272812008Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3.47
171225102006The incidence and anatomic site specificity of chromosomal translocations in primary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in North America.43


Pubmed IDLast YearTitleAuthors
108459242000BCL10 gene mutation in lymphoma.Du MQ et al
99894951999Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types.Willis TG et al
17289481992Cytogenetic study of B-cell lymphoma of mucosa-associated lymphoid tissue.Wotherspoon AC et al
103198631999Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32).Zhang Q et al


Fusion gene

IGH/BCL10 IGH (14q32.33) BCL10 (1p22.3) M t(14;18)(q32;q21) t(1;14)(p22;q32) t(3;14)(p13;q32) , IGK/BCL10 IGK (14q32.33) BCL10 (1p22.3) M|IGK/BCL10 IGK (14q32.33) BCL10 (1p22.3) M t(1;2)(p22;p11)
Atlas Image
t(1;14)(p22;q32) - Courtesy Eric Crawford, Genetics Associates, Inc., Nashville, TN 37203, USA


Gianluigi Castoldi ; Antonio Cuneo

t(1;2)(p22;p12) IGK/BCL10
t(1;14)(p22;q32) IGH/BCL10

Atlas Genet Cytogenet Oncol Haematol. 2001-01-01

Online version: http://atlasgeneticsoncology.org/haematological/2044/t(1;2)(p22;p12)-igk-bcl10-br-t(1;14)(p22;q32)-igh-bcl10

External Links