t(3;13)(q27;q14) LCP1/BCL6

1998-01-01   Jean-Loup Huret , Jean-Luc Lai 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

NHL

Phenotype stem cell origin

found in various types of NHL (e.g. Burkitts lymphoma andfollicular lymphoma); the translocation is therefore likely to be a secondary event in the course of the disease.

Epidemiology

only 3 cases available to date; all three are adult female patients

Cytogenetics

Cytogenetics morphological

found twice (out of three occurrence) as asecondary anomaly: following the well known t(8;14)(q24;q32) and t(14;18)(q32;q21)

Additional anomalies

del(6q) found in 2 of 3 cases; the karyotype may be complex

Genes Involved and Proteins

Gene name
BCL6 (B-Cell Lymphoma 6)
Location
3q27.3
Gene name
LCP1 (lymphocyte cytosolic protein1)
Location
13q14.13

Bibliography

Pubmed IDLast YearTitleAuthors
96149131998Translocation (3;13)(q27;q14): a nonrandom and probably secondary structural change in non-Hodgkin lymphomas.Laï JL et al

Summary

Fusion gene

LCP1/BCL6
Atlas Image
t(3,13)(q27; q14-21), t(14;18;(q32;q21) G - banding - Courtesy Jean-Luc Lai

Citation

Jean-Loup Huret ; Jean-Luc Lai

t(3;13)(q27;q14) LCP1/BCL6

Atlas Genet Cytogenet Oncol Haematol. 1998-01-01

Online version: http://atlasgeneticsoncology.org/haematological/2053/t(3;13)(q27;q14)-lcp1-bcl6

External Links